An
exciting new area of research in antibiotic molecules is the study of the many
metalloenzymes using both copper and zinc. It is well known that infections
cause depletion of these metals, especially zinc, and that supplementation of
zinc during acute infection stages along with vitamin C assists in shortening
recovery times and reducing symptoms for colds.
The
complex new field Metalloenzymes is beyond the scope of this website to describe,
but may be the subject of further ongoing research in a few months. Keep
looking to our website.
In
the mean time here is an overview of MetaloEnzymes to set them in perspective.
Metals
and near metals provide a + ionic bonding valence. They bond to atoms that
share electrons, with a – ionic
valence, like oxygen, sulphur, chlorine, fluorine, etc. Elements considered metallic are: Sodium Na;
Calcium, Ca, Zinc, Zn;, copper, Cu, Magnesium, Mg; Manganese, Mn; Tin, Sn
(Stannous); Silver, Ag;, Gold, Au; Aluminum, Al; Cadmium, Cd; Iron, Fe; Nickel,
Ni; Chromium, Cr; Cobalt, Co; Selenium, Se; Mercury, Hg; Lead, Pb; Silicon, Si;
Uranium; U.
Some
metals are needed in trace amounts (Se) and at higher levels or certain forms
are toxic: Mn, Se, Ni, Co, Cr, Hg, Pb,
micro-Si. Some elements are problems in
the metal handling and battery industries. Others are problems in the
semiconductor industry. Some toxicity issues are related to the form of the
colloidal and nano particles, like Si.
Other
issues relate to a tight range in non-toxic tolerance or with build up without
adequate or fast enough means to flush them from our system (Ni, Fe, Hg, Pb, Mn, Al, Si, Au, Sn…) Intake
can be environmental: medical injections, medicines, contaminated or traces in
supplements, water, mineral dust, contaminated factory working conditions, food
intake (Hg, fish), smoke and air pollution.
Although
all metals can be toxic in excess, the following can be considered particularly
toxic: Mn, Au, Al, Ni, Hg, Cd, Cr, Pb, Se.
Aluminum
is used as an adjuvant in vaccines. Recently the measures for exit rates for
the Al in muscles have been proven to be much slower than assumed. This
explains some of the vaccine related hyper immune observations and reopens the
serious question of combined-vaccination safety due to aluminum toxicity. The significance of certain obscure medical
papers in this regard have not been recognized by cognizant controlling
authorities.
Even
Iron, so essential to our oxygen transport, has a genetic subpopulation that
cannot remove it; and so, for them, it can rise to toxic levels.
Radioactive
SnF is used as a marker for bone infection radioisotope imagery, proving the
affinity of this molecule to the site of the infection. CaF has a similar affinity and if taken in
small amounts controls the infection and the growth of the bone calcifications.
Eating
SnF (Stannous Fluoride) toothpaste has been reported as a helpful
countermeasure for painful ostiomyelitis and bone calcification colonies of
bacteria. The bone plaques attenuate the antibiotic penetration. In vitro biofilms attenuate antibiotic
effectiveness by factors of hundreds to sometimes over 1000 times. For bone infections even more penetrating
power is needed. Biofilms, plaques, granulomas and calcifications obviously
invalidate the customary tetracycline antibiotic protocols dose levels by a
wide margin, but to a degree so great that it renders useful antibiotics
clinically useless without a boost. Serapeptase enzyme can provide a biofilm
destroying factor that will potentiate the antibiotic.
It
is also known that the tetracyclines beneficially change the activity of
certain metalloenzymes. The
codification into dosage limiting rulebooks of the low dose antibiotic
protocols by doctrine to minimize antibiotics use has had many fatal effects
and has let to much suffering. In such
cases as ostiomyelitis restrictive treatment rules leave the patient without a
prescribable level of antibiotic
treatment. We see similar rules and custom against treating Lyme cases where
the combined long term antibiotics are necessary but unconventional and doctors
prescribing them are persecuted with false claims of malpractice.
Vitamin
C has a chelating effect. Chelation combines metals into bound forms to permit
its transport and removal around and from the body. Removal is certainly good for toxic metals like aluminum,
mercury, chromium, cadmium, and uranium.
After DHEA chelation it usually requires additional supplementation to replace lost Calcium, Zinc, Copper and Magnesium.
Zinc,
copper, silver, and gold are associated with arthritic healing. They form a
group in the periodic table of elements with an ionic bond valence of +2. Thus
when they bond to other molecule parts they bond to atoms providing two
electrons. Oxygen provides –2. With this +2 valence, they can bond in place of
each other, provided there is space in a constructed enzyme molecule for them
to fit. They will take these places
depending on their relative concentrations, depletion and availability to in
the enzyme under construction. Copper and zinc separately work against arthritic
inflammation; but they may tend to work against each other in that increased
zinc intake reduces the chance of copper availability in certain necessary
reactions.
Certain
metal atoms provide molecular stability for enzymes. In their absence, the molecule is unstable, may miss-fold into a
pathogenic, dysfunctional shape or may just not work as effectively. The CoX-2 enzyme needs both Cu and Zn so if
your immune system is making a lot of Cox-2, and you deplete, the immune
functions may not work well or at all.
It might be better, just to stop making defective enzymes if the metals
needed are in short supply.
This
leads to some nutritional folklore that may have some real dynamic metal
deficiency causes. Reduce the metal deficiency and the immune system works more
like it should; and both chronic and acute microbe resistance is higher.
The
need for Zn and Cu is small, and the amount needed can be quite dynamic, with
acute infections and immune reactions highly active, stores are quickly
depleted. Both microbes and the host
need metallic atoms for their enzymes.
Chelation bonds to chelation agents and makes them partly
unavailable.
It
is well known that zinc depletion increases infection susceptibility leading to
infection persistence.
Chelation
can clear the deck of harmful microbe produced heavy metal (Hg, Cr, Pb, etc )
metalloenzymes components and also reduce the concentration to deplete the Cu
and Zn Supplies, meaning beneficial metal ion supplements are instantly
necessary.
Vitamin
C also performs chelation; so if you take a lot of AA, you may need to take Cu
and Zn supplements to avoid depletion levels.
Actions
of metalloenzymes, production of defensive metalloenzymes, and pathogen
generated metalloenzymes are now new regions of intense study. For example the
possibility of the body’s building defective defensive enzymes in the absence
of the needed metal atoms, and the presence of alternative metals needs to be
understood.
Because
there are thousands of metalloenzymes, just fully describing the following, for
each metalloenzyme, is a tall task: