Multi-Factor Protocols:  KetonicProtocols.htm

Index:

  1. How and Why: Ketosis  + AA + Antibiotic Fats + Nutrition + Anti-Inflammatories = > Potentiate Antibiotic Protocols:
  2. AA (Ascorbic Acid = vitamin-C) Actions:
  3. How to tell the AA dosage you need:
  4. Microbes need sugar and body can work without much sugar at all:
  5. Ketosis: how to induce it and test for it:
  6. Microbes invade cells: red and white blood cells; epithelial tissue and immune cells
  7. How Ketosis changes the cells’ functions:
  8. How cells use energy:  Citric Acid (Krebs) Cycle, ATP, and CoQ10
  9. Nutrition Factors:  Tropical Oils and Antiviral Omega 3 oils
  10. Jarish Herxheimer reaction (Herx):
  11. Herx Management:
  12. Vaccines Are A Threat if you are chronically ill.
  13. Time cycling the antibiotics:
  14. A side comment on histamine:
  15. Olive Leaf Extract Adjuvant: Broad spectrum antimicrobial
  16. Tropical saturated oils are protocol adjuvants: POPG Lung Surfactant
  17. Plaque and Biofilm antibiotic resistance: Serrapeptase description
  18. Sugar Spoofing Reduces Bacterial Virulence: Xylitol is a sweet biofilm buster
  19. Aspartame, Stevia and Aloe Vera: Artificial Sweeteners’ Effects.
  20. Hyperglycemia and Inducing Relapses:
  21. Acid/Base balance in the body:
  22. Prostatitis: AB plus biofilm busters.
  23. Cancer Bicarbonate of Soda Antacid:
  24. Gut Dysbiosis: A result of antibiotic protocols:
  25. Gut Infections:
  26. CASE HISTORIES:

·        Periosteal Arthritis, Ostio Myelitis Bone and Joint Infection:

·        Remarkable Alzheimer’s Reversal by Ketosis diet and Coconut oil:

·        Gut Health Case Histories:  Fermented Sauerkraut Cures Dysbiosis and Lactose Intolerance.

·        EMU Oil Case Histories:  Penetrating, transporting oil

·        DMSO  DiMethyl Sulfoxide: DMSO is a transport medium.

  1. DIETARY REFERENCES: Books
  2. MICROBES VS DISEASES REFERENCES:

·        Table: Oral Antibiotics For COPD Treatment of Acute Exacerbations of Chronic Bronchitis

  1. Saturated Oils Nutrition Factors Technical References:
  2. Dr Frederick Klenner: (1953) Early Clinical Usage of Vitamin C.  Quote:
  3. More Remarkable Klenner on Nutrition:  Multiple sclerosis (MS) and (MG)
  4. Other References: Essential Nutrients, POPG Chemistry

·        POPG Chemistry:

·        Gut Health:

·        Ascorbic Acid, Hyperglycemia, CoQ10 and Orthomolecular Nutrition  --John Ely

·        Papers on Vitamin C used in Ortho Medical Nutrition.  -- Klenner, Cathcart, Pauling, Stone 

How Low-Carb Ketosis + AA + Antibiotic Fats + Nutrition + Anti-Inflammatories Potentiate Antibiotic Protocols:

In order to maximize the kill percentage one needs a protocol that has multiple factors. The following conceptual formulas illustrate how the combined protocol factors work in theory.

 The combined survival fraction is the product of  the survival fractions of the several lethal elements.

If kill percentage is K%, define kill fraction as 0 < Kf <1 by K%/100.  

Survival fraction:  Sf = 1- Kf and Kf = 1- Sf.

Sf = (Sf1) x (Sf2) x  (Sf3) x (Sf4) x….

Sf = (1-Kf1) x (1-Kf2) x  (1-Kf3) x (1-Kf4) x….

By using multiple antibiotics or adjuvants that have different principles of operation one can multiply the effectiveness, and reduce the chance of developing antibiotic resistance. 

SfAntibiotics = (SfAntibiotic1) x (SfAntibiotic2) x  (SfAntibiotic3) x (SfAntibiotic4) x ….. Combined Antibiotics

  SfAntibiotics = (1-KfAntibiotic1) x (1-KfAntibiotic2) x  (1-KfAntibiotic3) x (1-KfAntibiotic4) x …..

SfTotal = (SfAntibiotics) x (SfAntibiotic-Fats) x  (SfAA) x  (SfAnti-Inflammatories) x ….. Combined Protocol

  SfTotal = (1-KfAntibiotics) x (1-KfAntibiotic-Fats) x  (1-KfAA) x  (1-KfAnti-Inflammatories) x …..           

S%Total = 100 x SfTotal

In order to minimize the survival percentage one uses more factors and tries to minimize each survival factor.  Where replication occurs one tries to block the success of it, by targeting the factors leading to its success and reducing the odds by functional changes in the in vivo environment. One kill factor is Ketosis. John Ely describes the mechanism of glucose ascorbate antagonism (GAA) and Aggressive Glycemic Control (AGC). See note below: 14

Many other Kfs are Anti-microbial antibiotics. One is sugar or nutrient starvation. One is tryptophan starvation. 15 One is molecular spoofing. One AA feature is neutralizing a spreading factor. One Kf is raising the body temperature or inflammation zone temperature by hot water spa or sauna. One is from eating coconut oil that kills pathogenic (HIV and other) gut microbes by dissolving their waxy lipid membrane coatings. One repeated Kf is taking vinegar regularly (3x/day) to sterilize the gut membranes after a clean out flush. One is by a magnesium hot compress. One Kf is topical melaleuca oil or topical DMSO plus oil of wintergreen or camphor. One Kf is oral salt + AA + garlic oil.  One Kf is produced by Electromagnetic Rife machine treatment, producing a Herx reaction. One Kf is repeated HBOT oxygen therapy which kills anaerobic bacteria in tissues at high enough pressures. One KF is microbe <to/from> immune-cell signal blocking, by immuno-suppression POPG derived from palmitic acid. Several are a mineral antagonist, salt/silver/zinc. Many are eating anti microbial foods. Many are vitamin and nutritional deficiency related. Many are spices and herbs like olive, oregano, melaleuca oil and aloe vera. There will be more specific new ones that we will discover in the future, and old forgotten ones we will find in the various nations’ medical archives and learn how to implement.

AA (Ascorbic Acid = vitamin-C) Actions:

AA has two effects. One is to make it more difficult for the invaders to penetrate their target cells that they use for replication.  The other acts inside the cell when ROS- oxidized AA kills the invaded cell with its compromised mitochondria.  The effect of anti inflammatories is also multiple.  One is to reduce the signaling of the microbe to the target immune cells that they would invade. This slows the replication. Another is to turn off the generation of the ROS that converts antioxidant AA to the oxidized for Dehydro AA (DHA).  A third is to reduce the formation of plaques, granulomas, lesions, and calcium nodules that wall off and protect the microbes from the antibiotic.

Reactions are competitive and depend on concentrations:

Chemical reactions depend on the concentration of the various molecules.  The uptakes into cells for sugar and for DHA are competitive.  If the sugar concentration is much greater than that of AA then most of the uptake will be of sugar, feeding the microbe cellular invaders.  If the blood is starved for sugar and DHA is present in high concentration, then the cells are more likely to uptake the DHA.  This is to say that sugar interferes with the action of AA (= DHA) acting as a initiator of invaded-cell death.  So the effectiveness of AA is improved by the low sugar Ketosis mode. It is worsened by hypoglycemia and diabetes.

Similarly, the action of the Antibiotic fats, the monoglycerides of the saturated tropical oils of the palm plants are in proportion to their concentration.  Since the nation’s diet prefers some fats above others, starving the body of saturated palm fats reduces several natural antibiotics that have been shown to help control both bacteria and viruses.  COPD and bacteria caused plaque is likely to be made worse by too little palmitic and lauric fatty acids. The attempt to reduce cholesterol is misguided and it leads to labeling saturated fats as bad when the opposite is true.

How to tell the AA dosage you need:

If your gut does not get loose, you need to take more AA.  If gut gets loose from eating the AA, you are taking too much or too often.  If you are sick, with high levels of AA intake, you should feel a reduction of the feelings of sickness.  If sickness symptoms come back: pain, itch, ague, etc, then you are out of AA and you need to eat more of it, immediately. Since AA is stored in the lenses of the eyes the degree of focus accuracy may fluctuate with systemic AA depletion.  Some persons know that when their eyes go out of focus, it indicates that they are low on AA and need to eat more.

You can increase AA intake and effectiveness by making and using Liposomal AA. Combine powdered AA, Water, Lecithin, [and coconut oil] in a blender. Following this an ultrasonic cleaner is used to micro-homogenize the AA.  This makes oral Liposomal AA which is more effective than IV AA.  One gram of this AA is said to be equivalent to 7 grams of sodium ascorbate IV AA.  The combined encapsulated AA passes thru the gut more readily and it also is more bioactive in the body.  See the video: How to make Liposomal AA.  See the list of  all the Vitamin C Foundation Videos.

Microbes need sugar and body can work without much sugar at all:

Normal body cells do not need much sugar for energy; they can also use fats and proteins. But cancer cells, microbes and infected cells need a lot of various microbe specific sugars.  AA does not get imported into cells very much, but DHA goes into cells in very much greater amounts. But this happens only if you are eating a lot of active AA to start with, and are not eating much sugar.

Ketosis: how to induce it and test for it:

Benign ketosis (<15-30 grams of carbohydrates per day), see Atkins Diet induction phase; it really lowers blood sugars. You can get ketone test strips at any pharmacy to test if you are in the ketosis state.  You may notice your breath smells like nail polish remover. This is because you have a little acetone in your blood. Acetone is in nail polish remover.

With ketosis: Liver stops converting glucose to fats for storage. Liver switches to use fats and your cells’ mitochondria in the Krebs cycle burns the fats extracted from your blood. Lipid HDL and LDL drop into the “normal” range.  Ketosis starves system of sugars.  Starches we eat are converted to sugars. So ketonically low carbs means very low sugar in our blood.

Microbes invade cells: red and white blood cells; epithelial and tissue cells; especially, they invade immune cells chemically-signaled to kill and eat them.

Microbes in chronic, persistent infections invade your epithelial cells and your immune cells, among others, in certain organs that specific microbes have matching molecular “hooks” to attach to.  They use hyaluronic acid Lysase, an enzyme that dissolves your cell walls, to penetrate your cells and to inject their DNA or RNA into their target cells. 

Inside invaded cells, microbial genetic recipes cause the mitochondria to work differently and to dysfunction. The microbe parts steal CoQ10 the energy oxidizer molecule and sugar from your cells and you feel tired.  If you take more Co enzyme Q10 to make up for this you will feel almost normal.  The invaders need sugar and CoQ10. But your cells can live by converting Fats and Proteins into the acetyl CoA that is actually the fuel. The invaders --- bacteria, viruses and fungal forms eventually replicate and kill the cell to get out. We have seen striking pictures of their exit.

How Ketosis changes the cells’ functions:

Ketosis: In the absence of sugars, DHA (oxidizing form of vitamin C) takes sugar’s place. This means that an oxidizing molecule is imported and the microbe components try to use it as fuel. This does not work and it kills the mitochondria and the infected cells and the microbes that import it. The invaded cells’ microbes’ parts can work with certain sugars, but cannot burn fat or protein as well. So the cell dies.

Cell Wall Deficient (CWD) bacterial invaders and infected cells need lots of sugar. Soft drinks and refined starches provide this. So see the Dr. Atkins diet materials for the low carbohydrate diet’s induction stage rules to make sure you have somewhat less than 15 to 30 grams of carbohydrates and are not eating any of the forbidden food elements or eating too much.

You need enough DHA to act as if it was sugar, and the cells normally metabolize a very large number of grams of sugar. So you need to swallow the AA as if it were food. We usually do not eat this much of vitamin C, by far. We should not get it as a food component (like fruit juice) because it comes with too much sugar. But if you think of pure AA as a sugar replacement food that you need, then  30 to 150 grams per day of AA is not much if it were meat or candy. 

CWD bacteria of various species and strains prefer strain-specific sugar molecules.  High Fructose Corn Sugar, (HFCS) is a mix of several sugars and nourishes most varieties of CWD bacteria. There is a lot of HFCS in soda drinks and in junk food.  Instead, your diet should be meats, fats, and natural fibrous vegetables that have low sugar and starch content. 

See the web for Atkins Diet recipes  and foods and how to limit the amounts you can eat.  You must maintain a strict low carbohydrate diet, to stay in ketosis mode.  No bread, potatoes, rice, pasta, breakfast foods, pastries, pies, donuts, corn, carrots, yams, starchy beans, pasta, etc.  Perhaps your intake is about 500 calories/day. You can eat meat, fats, un-breaded fish, shellfish, a little cheese, but no milk, buttermilk, cottage cheese and ice cream.  No condiments that contain sugar.  Read all the labels and insure the number of grams of carbs is in the range for the Atkins diet induction. You can stop the ketosis after your symptoms stop and you no longer need to lose weight. When on Atkins diet, vitamin supplementation is necessary.

How cells use energy: Citric Acid (Krebs) Cycle

Cells use a molecule called ATP for energy.  It is made in a recycling reaction loop called the Krebs cycle (Aka, citric acid cycle) that uses as its “food” a super versatile enzyme, Acetyl-CoA, made from Fats, Carbohydrates or Proteins by  a process called catabolism by mitochondria in cells. In the liver, with ketosis ongoing the cells convert fats to glucose, the primary sugar the body cells need. Too much dietary citric acid may promote bacterial growth.

Catabolism takes place in cells’ mitochondria to convert fats and produce Acetyl-CoA.  Then the Krebs cycle reactions use Acetyl-CoA to make ATP, the cell energizer fuel that drives all the other cells’ anabolic, energy-consuming reactions.

In the mitochondria, CoQ10 is the oxidizer and Acetyl-CoA is the fuel and NADH (Coenzyme-1) is the helper enzyme, so called spark plug.  So in all cells from muscles to brain, deficiency of CoQ10 will limit the cells’ energy use.  Your body needs about 500 mg of CoQ10 per day, made by the mevalonate chemical pathway, where cholesterol, CoQ10 and Heme is made.

When you get older you do not make enough CoQ10 and may need supplements.  If you have chronic intracellular infections, and we all do, then you need CoQ10 supplements. The mevalonate pathway is blocked by statins. Statins really starve the body’s cellular (nerve and muscle) regeneration process by limiting cholesterol, CoQ10 and Heme, a component of hemoglobin.  Heme is used in blood cells to transport oxygen throughout the body. Cholesterol is the source of our sex hormones and is needed to keep nerves and muscles healthy and to rebuild them as needed.

So if you starve the carbs, then the Acetyl CoA fuel sources become fats and protein, and your cells work.  But microbes prefer non-glucose sugars so ketosis starves them and they suck up DHA that is an oxidizer, not a food. That further starves the cell and oxidizes the mitochondria. This kills the invaders’ CWD L-forms and also kills the invaded cells that have ingested microbial DNA. This blocks intra-cellular microbe replication. Because of their sugar preferences certain microbes are more sensitive to ketosis than others. So avoiding of HFCS and dietary sugars is best.

Nutrition Factors:

According to Mary Enig:  The cause of heart disease is excess refined vegetable oils and hydrogenated (Trans) fats; excess refined carbohydrates: sugar and white flour; mineral deficiencies: magnesium, iodine, selenium; deficiencies of natural unrefined vitamins: A-complex/B-complex/C; deficiencies of antioxidants like vitamin E complex; and the disappearance of dietary antimicrobial fats: animal fats (butter) and tropical oils: coconut, red palm and palm kernel oils.

One could also add Lysine, Proline and Carnitine deficiencies.  AA + Lysine è Carnitine, needed for muscle and tissue health.  Lysine is anti viral, especially for the human Herpesvirus family: HHV1&2 (HSV=cold sores), CMV, EBV, H. zoster = Chicken pox and shingles, etc.  L-arginine promotes HHV growth. See Pauling protocol for heart disease.  Excess lysine and low arginine spoofs the microbes molecule building process.

Tropical Oils contain: Saturated fatty acids---Lauric, Palmitic, Caprilyic, Myristic; CoQ10; tocopherols and tocotrienols (vitamin E variants); and antiviral vitamin A variants. Our packaged vitamins A & E are monomolecular not a natural mix and do not have all the many process-dependent, unique shapes we need. Natural, gently refined tropical oils are not heated excessively, not bleached, not oxidized and not hydrogenated; they are made that way for the nutrition trade. They contain the wide spectrum of molecular shapes you may need in ways that go beyond our simplistic theoretical knowledge of their actions.

 The saturated fatty acids do not oxidize easily or turn rancid rapidly. Rancid fats are toxic. If rancid or hydrogenated (trans) fats were used to make cholesterol some resultant molecules produced would be toxic to nerves. Statins cause cholesterol starvation, opening the way for toxic oil variant molecules to take the place of the missing cholesterol, leading to nerve and muscle cell dysfunctions and cell replacement molecule errors that shorten our life by increasing our aging rate.

Tropical oils are very readily used as fuel, they pass the blood brain barrier, and they dissolve the CWD membrane to kill CWD forms and viruses system wide.  Monoglyceride forms of Lauric, Caprilyic, Palmitic, Myristic are antimicrobial. Lauric and Palmitic are most essential to systemic anti microbial health.  Daily 2 to 3 tablespoons of tropical fats: coconut, red palm oil, and palm kernel oil or a mix of the three to get all the natural nutrients with the widest range in molecular shapes. We will use the active shapes and burn the others. A case history below shows Alzheimer’s improvements.

Antiviral Omega 3 oils are also essential to health. They come from fish and cod liver oil, along with vitamin A.  They normalize and lower excessively high allergic immune responses.  Omega 6 oils are also essential. However, Omega 6 oils may add to inflammation and have antimicrobial effects.  This can be used to enhance the microbe killing factors. Most doctors avoid prescribing the O-6 oils because of the induced Herx like immune upsurge.  Instead of avoiding O-6 they should be in the diet and the AA anti oxide intake should be increased to neutralize the increased inflammation.  The best way to get the natural O-6 (9%) and O-9 (Oleic=~83%)  is from natural foods (sunflower seeds) rather than extracted refined oils.  One effective way is from eating a modest amount of sunflower (O-6) and flax (O-3) seeds as a snack, several times a day without missing a day. See nutritional components of sunflower seeds. See Case History sunflower seeds at the end of the list of personal case histories.

Vitamins  A, B6, B12, C, D, E are related to dependencies and infections.  Vaccine induced high vitamin A dependency has been demonstrated as an allergy-related cofactor in Autism.  Active allergic responses rapidly deplete ascorbic acid (AA) which is vitamin C.  Vitamin D is essential to immune system activity. Too low vitamin D contributes to a depressed immune system. 

Jarish Herxheimer reaction (Herx):

Antibiotics kill cellular microbes and create Jarish Herxheimer reaction with reactive oxygen species ROS: H202 and NO. When active vitamin C (Ascorbic Acid) molecule meets ROS molecule they react to disable the oxide and this makes the oxide/oxidizing form of AA, called Dehydro AA (DHA). The antioxidant, active form of AA neutralizes toxins of the Herx reaction and it is a powerful histamine reducer. As ROS levels drop the histamine levels also drop.  “Large” amounts of AA are eaten frequently, Start with 3-6+ grams as often as every two hours.  Effective dosage for a Herx condition is about 24 grams per day or more.  Google [Cathcart Titration to Bowel Tolerance]. If you take large daily amounts of AA you should also take vitamin E at 400 units per day. –Ely.

Herx Management:

Because this protocol depends on ROS to convert AA to DHA, totally suppressing the antibiotic initiated Herx reactions by use of immune-suppressing drugs defeats the purpose of generating DHA to kill infected cells.  However for very severe inflammatory conditions, the following measures can help to reduce the severity of the Herx reactions.  Cortisone and prednisone can reduce inflammation, granulomas, scleroses, lesions, plaques and microbe (viral) replication. Benicar, an angiotensin release blocker (ARB) can block the cytokine cascade inflammation flare and allow increased antibiotic dosages. TNF blockers also stop inflammation. Granuloma formation walls off TB bacteria and protects them from antibiotics. So anti inflammatories functionally and statistically potentiate antibiotic actions.

Omega 3 oils are anti-inflammatory Omega 6 oils are inflammatory. For some persons peanut oil is highly inflammatory.  You may need to have a blood analysis for food allergies to determine what foods to avoid to reduce the Herx intensity or to eat to increase the intensity.

During the Ketonic protocol, eating patient specific allergy-producing foods, like peanuts or other foods known to turn on immune system may be used if the Herx reaction does not rise to the level needed to convert AA to DHA. An experienced physician who will work closely with you over the period of administration, best can handle managing the proper balance of inflammation and immune suppression. Fire and forget is not the mode of treatment. In the absence of the physician, every hour, you have to learn to listen to the feelings of pain, tingling and irritation to sense the action of the foods and medicines and learn which combinations improve things and which changes make things worse.

Vaccines are a threat if you are chronically ill.

It has been observed that penicillin allergies usually vanish if you have high levels of tissue AA.  Therefore some drug allergies may be Herx reactions intensified by low levels of systemic AA. 

Vaccines cause an elevated inflammation state by the action of the vaccine adjuvants. This elevation should go away in a few weeks, but for some persons and some vaccines the immune hypersensitivity is permanent; sensitizing the immune system to a inflammatory (Antioxidant-AA depleting) reaction to the next invasion by the natural microbe, to some normal tissue and neural molecules and/or to other toxins. 

All vaccinations should be avoided when the immune system is dysfunctional and especially when the patient or child is ill, because the vaccine shock will deplete the AA levels from low to dangerously low. SIDS deaths are the result of gut bacteria producing endotoxin depressing the AA/DHA ratio. Endotoxin predisposes the child to ENT inflammations, so if chronic ear, respiratory or gut inflammation exists, vaccines should not be administered. The gut should be purged, sterilized by vinegar and coconut oil intake and then repopulated with probiotic formulations.  Several grams and frequent intake of AA should be administered  to rebuild the stored AA supplies. Only when active AA shows in the urine, should vaccines be administered.

 

Time cycling the antibiotics:

Time cycling the antibiotic is useful because the microbes CWD forms switch forms within minutes in vitro and in vivo to protect themselves from the antibiotic.  Lyme CWD forms roll up in tight balls, then unroll later. If a two-day on/off/on/off antibiotic cycle is used each cycle reduces the population by an assumed 30%, after 20 cycles (40 days), the Sf20-cycles = 1/(1-.3)20 = .0006.

When this is combined with other protocol elements like Lauric acid to attack microbes’ membranes and palmitic in the lungs to reduce immune signaling, the total reduction can be dramatic. 

Immune suppression and antibiotics work well together because the sclerotic plaques wall off the microbes and protect them. The immune suppression increases the kill percentages and speeds. Prednisone or TNF blockers alone used as an antibiotic adjuvant with conventional TB antibiotics showed a reduction of relapse rate from ~30% to ~2%.

A side comment on histamine:

Antihistamines might seem to be helpful in severe Herx reactions, but with the high AA blood levels of this protocol, there should be very little histamine produced.  High histamine is a result of the combination of AA depletion and NOS, not a cause of it. With high ROS and not on the high AA protocol, toxins and allergies and acute infections cause AA depletion. When AA levels get below .7 mg/100 ml the histamine levels start to increase exponentially. See the graph in this hyperlink. Histamine is toxic in high levels.  Histamine food poisoning (e.g, from decomposed tuna or certain bacteria in cheese) is evidenced by a red skin flush over most of the upper body.

Olive Leaf Extract Ajuvant:

Olive leaf extract is a broad spectrum antimicrobial.  When we were patients of Dr. A. Robert Franco, he included this in his nutritive protocol. Here  is an example of how it works.

Other protocol adjuvants can be found in food, especially in ethnic recipes and condiments.  See our page on Antiviral Foods. You may find additional adjuvants to improve kill rates among the antiviral foods, spices and herbs which you can eat regularly in normal food portions.

Tropical saturated oils are protocol adjuvants:

POPG, a lung surfactant derived from palmitic acid (butter and palm oil) combined with palmitic acid is an ideal surface tension reducer, making breathing easier.  It also interferes with the inflammation signaling between microbes (bacteria like mycoplasma pneumonia and viruses like RSV) and immune cells. See our discussion of COPD countermeasures.

Since the microbes are equipped to invade the immune and epithelial cells, if the immune cells attack the microbe, they will be invaded and turned into replication factories, so blocking the signaling blocks the replication and granuloma formation.  This may be how prednisone blocks replication for Coxsackie’s and other viruses.

AA’s proven action blocking hyaluronic acid lysase enzyme the, bacterial penetrating/spreading factor reduces cell invasion; ROS +AA =>  DHA which kills the invaded cells. Killed cells release toxins contributing to the Herx reaction inflammation, making more ROS and requiring increased AA intake.

Plaque and Biofilm antibiotic resistance: Serrapeptase book

Eating SnF2 (Stannous Fluoride) toothpaste has been reported as a countermeasure for painful ostiomyelitis and bone calcification spurs, colonies of bacteria. The bone plaques attenuate the antibiotic penetration. In vitro biofilms attenuate antibiotic effectiveness by factors of hundreds to sometimes over 1000 times.  For bone infections even more antibiotic penetrating power is needed.

Biofilms, plaques, granulomas and calcifications obviously invalidate the customary tetracycline antibiotic protocols dose levels by a wide margin, but to a degree so great that it renders otherwise-useful antibiotics clinically useless without a boost. Before healing can take place sclerotic structures must be broken down. The proteolytic enzymes do this.

Use Serrapeptase and bromelain enzymes to provide a biofilm destroying factors that will potentiate the antibiotic activity by destroying the colonies’ protective calcifications and granulomas. See: Augmentation by serrapeptase of tissue permeation by cefotiam, a new cefalosporin. Serapeptase enzyme helps COPD and may augment many other protocols.

Some cautions should be observed.  Use in cases of hemorrhagic (bleeding) stroke might be counter indicated, while use in cases of ischaemic (clotting) stroke can be beneficial. Warnings relate to enhancing actions of blood-clot-preventing medicines.

Case histories report rapid breakdown of scar tissue and rendering hard tissue more flexible. Sprain recovery rates are improved and the period of painfulness is reduced, reportedly, using serrapeptase. An amazon.com case history reports serrapeptase having a positive effect on ASD inflammation after initial flare.  Amazon Case Histories. Other Serrapeptase case histories.

Claims of no adverse effects may be mistaken, see our website notes and cautions on using serrapeptase.  Protocols for taking serrapeptase sometimes run for more than a few months. Herx reactions have been reported with teardown of biofilm colonies.  So the reports of no adverse reactions are ignoring the Herx reactions reported elsewhere.

 

Sugar Spoofing Reduces Bacterial Virulence Using Xylitol as a Sweetener:

Fructose is a 5-carbon monosaccharide sugar. Glucose is a 6-carbon monosaccharide. Sucrose is a bi-saccharide sugar molecule combining fructose and glucose with an easily split oxygen link.  Xylitol is a 5-carbon sugar alcohol sweetener that can be substituted for sucrose in prepared food, chewing gum and candy.  It was used extensively in Europe during WW2 as a sugar substitute, with reported health benefits.  It has both antibacterial and antifungal properties. 

Different bacteria strains exhibit preferences for particular sugar molecules, so restricting all sugars in the blood tends to starve many bacteria and yeasts that cause chronic maladies. Many bacteria and yeasts do not have the genes to use Xylitol in the absence of sugar in the host system. Given a Ketonic state plus Xylitol, bacteria will die off and a few will evolve to a new form that uses Xylitol and is less pathogenic.

Xylitol is normally toxic to bacteria that are programmed to use fructose and glucose. In vitro studies show a selective long-term change in the sugar-using bacterial genetic programming of the survivor microbes fed persistently with Xylitol in place of 6 carbon sugars. See Negotiating with Bacteria.

Xylitol causes gut discomfort with too high an intake level, because it upsets the normal sugar using microbiome. It blocks sugar fermentation by blocking the adhesion of sugars to epithelial and other cells.  In lower levels of intake it can change the microbiome in other parts of the body. Slower increase in dosage can overcome the Xylitol caused gut disruption problems. 

Xylitol has been used as a sugar substitute in treating diabetes and hypoglycemia. Its metabolism in the body is independent of insulin. Thus it does not build stored fats. Xylitol should be used in place of sugar in recipes to reprogram bacteria and yeasts to attenuate pathogenicity and virulence.

Studies have shown that about 10 grams/day total of Xylitol intake, supplied by chewing gum, provided throughout the whole day can lead to the change of the body’s (mouth/ear/respiratory/urinary/gut) microbiome. However it may take months of persistent gum use to do this permanently.

With use of Xylitol-sweetened chewing gum, the mouth bacteria causing dental plaques change to Xylitol tolerant forms and lose their virulence, plaque forming abilities, and much of their pathogenicity.  Long lasting changes to the mouth’s microbiome have resulted, reducing the rate of formation of dental plaques.   This plaque-resisting property lasts for many years after long term Xylitol intake has stopped.

Xylitol studies have inferred a reduced adherence of microbes to epithelial structures in the respiratory tract, ear, esophagus, and the bladder. So long term low sugar plus Xylitol Ketonic diet change is likely to modify the virulence of biofilms and plaques related to COPD, GERD, and Cystitis/Prostatitis/Overactive Bladder may be inferred. Otitis Media study dosage. D-mannose (a 5 carbon sugar in cranberries) may work better than Xylitol for bladder infections, but a combination Ketonic-diet with of cranberries sweetened with Xylitol may work even better to disrupt adhesion of the bacteria in the urinary tract. A few cystitis blog case histories report IC symptoms relieved with Xylitol gum. (2 packs per day)

 Xylitol adverse side effects include short-term gut problems at high intakes.  Longer-term beneficial Xylitol diet antifungal effects may improve gut microbiome in cases of yeast proliferation --- thrush in mouth and gut epithelial yeast  colonization.  Caprylic, Capric and Caproic saturated fats in goat butter and goat cheeses are also noted as antifungal natural foods with medicinal properties if eaten persistently.

Xylitol powder is inexpensive and can be substituted for sugar in recipes, and used for a mouthwash. It can be found for sale on the Internet and at health food stores in bulk powder form. Five pounds may cost as little as $23.

It appears that Xylitol has system wide biofilm busting effects. It improves antibiotic and antifungal effectiveness in the presence of biofilm barriers, plaques, calcifications, and sclerotic structures.

Collection of Studies contains one study showing (20% to 40% reduction in Acute Otitis Media (AOM) cases) Bacteria affected by Xylitol include at least: Streptococcus pneumonia, Strep. mutans, Helicobacter pylori, and   and possibly many others, including fermenting microbes in the gut. AOM Microbiome    Normal Human Microbiome is still in study startup phase.

In 1994: “Bacteria causing AOM are: (Streptococcus pneumoniae, Hemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes) were found in 42% of all episodes; Pseudomonas aeruginosa or Staphylococcus aureus was found in 44% of all episodes. Pathogens of acute otitis media were found in 50.0% of subjects under 6 years old versus 4.4% of subjects 6 years or over at the first episode (p < .001) . Pseudomonas aeruginosa was found more often in children 6 years or older (43.5% versus 20.5% at the first episode, p = .052) . Pathogens typical of acute otitis media were less prevalent in the summer months (14.7% versus 52.2% for the first episode, p = .001), while P aeruginosa was more prevalent in summer (44.1% versus 16.4% for the first episode, p = .006). This suggests that while many younger children with acute otorrhea may respond to treatment with oral antimicrobiotic alone, outpatient therapy of older children may involve use of topical antipseudomonal agents that may be complicated by the question of the safety of such medications.”  Annals Otology Rhinology Laryngology, 1994 Sep, 103(9), 713 – 8

Persistence of these acute pathogens is presumed, based on CDC epidemiology and bacteriologic life cycle studies.  The body makes about 15 grams of Xylitol per day. Ketonic diet and additional intake of Xylitol can reduce the persistence-enhancing adherence and sugar metabolic factors.  AA can further enhance the invaded cell kill factors. Xylitol in place of sugar provides a dietary treatment plan for hyperglycemia and diabetes. Xylitol does not need insulin for human metabolism and it is not easily converted to stored body fat. Xylitol enhances Glutathione antioxidant recycling and activity.

Enhanced antibiotic effectiveness for Tuberculosis is likely to result from a Xylitol enhanced diet. The experimenters have not looked for evidence of M. tuberculosis evolving to less virulence with the presence of Xylitol. So Xylitol as a dietary antibiotic enhancer for TB may be worth trying. Xylitol vs ear infections.  See D-Manose vs. bladder infections.

Further reading on Xylitol is found at www.angelfire.com/az/sthurston/xylitol_natural_sweetener.html

 

Aspartame and Stevia, Artificial Sweetners’ Effects.

Aspartame at the level of several cans of diet Pepsi has been reported to decrease arthritic pains.  An earlier Townsand letter study showed increased morbidity. You should experiment to see how it may or may not affect your inflammation.

Stevia in dosages from 1/100th to 1/25th of the weight of doxycycline has increased the kill-percentage for Borrelia Burgdorfi, the microbe associated with Lyme disease.  Stevia in higher levels will show higher effectiveness in killing Bb.  Aloe Vera extract has been reported to increase AA systemic absorption by a factor of 3x.

 

Hyperglycemia and Inducing Relapses:

By using a multiple factored attack on invading microbes one can increase the kill fraction and reduce the microbes’ survival. When the treatment is stopped, hypoglycemia may return; a lower level relapse may result, but re-treating in the same manner can usually be successful. If relapse recovery is difficult, different antibiotics will target other microbes that the first did not kill.

Hyperglycemia and diabetes defeat the AA factor in the protocol: by blocking oxidized AA cellular uptake, plentiful sugar keeps oxidized AA from to attacking the microbes in invaded cells and sugar disables the effect of the AA disabling bacterial spreading-factor hyaluronidase enzymes. Dietary sugar provides nutrition for the bacteria. Multi-sugars like high fructose corn sweetener (HFCS) found in sodas condiments, and in many sweet pastries are the worst kind. They contain many different sugars matching the different molecule shape-dependencies of the various microbe strains.

Hypoglycemia and ketosis starve the microbes. In the diabetic condition benign ketosis with fat metabolism needs to be managed carefully. Close coordination with your physician is an important factor, but the patient should carefully monitor his feelings, sensations, food intake, and exercise levels in order to permit him to stabilize his sugar state to the region that is unfavorable to the microbes.  The Atkins Diet books in the references below are important guides to low sugar recipes.  

In one case a glass of orange juice caused a sensation of activity in the painful joint bone area of the ostiomyelitis infection. A second glass of orange juice, with all its sugar, introduced a permanent sensation and a severe relapse. Eating peanuts during the subsequent antibiotic treatment was used to intensify the Herx.  Eating honey-coated peanuts without the antibiotic and the AA was enough to induce a strong relapse. A number of Ketonic Treat-Relapse cycles were induced, with decreasing infection intensity as successive survival fractions decreased after each ketosis/starvation stage. In this way the microbes were forced to change forms: from antibiotic-resistant-dormant into sugar-using, antibiotic-vulnerable active forms by cyclic diet changes.

It is controversial whether this protocol can permanently eliminate a really persistent many-form microbe like Chlamydia pneumonia, Borrelia, Babesia, etc. It is our opinion that it will not, and our experience is that a multi factored treatment regimen must be repeated every year or so, prophylactically, to suppress the microbial resurgences that periodically occur, especially when stimulated by adding sugars back into the diet.

Acid/Base balance in the body:

PH of extracellular fluids in the body is critical for control of parasitic microbes. Vinegar (acid) can be used to sterilize the gut when pathogenic bacteria and viruses are present or when food poisoning occurs.  Eating vegetables (or drinking V8) can change a pathogenically acid PH from yeast infection to alkaline (base).  Drinking/eating sugars feeds yeasts that make acids.

Prostatitis: AB plus biofilm busters. McDonald’s Presentation;  UTI Biofilm Treatment in California;  Biocidin

Vinegar has been mentioned to attack epithelial calcium plaques (biofilms of nanobacteria) that protect other microbes that are susceptible to tetracycline (Minocycline or Doxycycline).  The Vinegar makes the antibiotic much more effective. This is related to UTIs and prostatitis. (possibly also cystitis)  Another combination is chelating EDTA suppositories with antibiotics (500 mg tetracycline) in combination. The higher dosage EDTA suppository formulation is most effective. The effective lifetimes of both must overlap to the greatest extent, which they do.

Cancer Bicarbonate of Soda Antacid:

One therapy for cancer uses Bicarbonate of Soda Na-CO3 to change blood and tissue PH from acid to less acid. This helps preserve the health of the lymph system and stop the spread of cancer to other parts of the body. The theory is that cancer cells are yeast infected or act like yeasts because they make acids. The less acid intercellular fluid blocks the extracellular migration of the infected cells and keeps them from forming new colonies.  Metastasis is inhibited for some kinds of cancer but not all types of tumor migrations are affected by the Na-CO3.  AA IV is effective at high levels as a cancer treatment. AA oxidizes to DHA which is mistaken for a sugar by the hungry cancer cells. Ketosis is important, sugar blocks the DHA uptake by the cancer cells. DHA is an oxidizing molecule, which induces cellular apoptosis.

Gut Dysbiosis is a result of antibiotic protocols:

The gut’s microbiome is disrupted by antibiotic anti-bacterial protocols. It is essential to frequently repopulate the gut with new lactose fermenting bacteria.  Shredded cabbage can be fermented at room temperature with a yogurt culture of known strains and purity. After fermenting for several days move culture to refrigerator to keep it for longer time. See our website below for how to do this. Eating the fermented sauerkraut several times a week keeps your gut healthy, preventing acquired lactose intolerance.

Gut Infections: HIV/AIDS; Measles/ASD; Yersinia entercolitica/Ankylosing Spondylitis; Unknown-gut-infection/Lower back pain.

HIV recovery or reversal has been multiply-reported, based on coconut oil and/or vinegar, taken incessantly, as a drug, multiple times a day. MMR live-vaccine sometimes causes chronic measles-vaccine-virus-strain gut-infection.  Persistent Autism related (ASD) neural inflammation might be reduced if this gut infection is eliminated. High amounts of Vitamin A or cod liver oil is antiviral, and has shown some success. Add coconut oil.  

Cleaning out the gut, sterilizing with vinegar and water, Rebooting the gut flora and repopulating gut with probiotics, buttermilk, and yogurt should help by revising the gut ecology. Maintain new ecology with daily coconut and palm oils and refresh probiotics with yogurt cultures and live yogurt cultured sauerkraut.

For IBS, a cabbage fermented culture was found to help. See: www.rejuvenative.com/catalog_one.htm or find similar products in health stores. Buy one use for starter and make your own fermentation with raw cabbage, lightly blended and plain yogurt with known cultures. (Ref 17) 

Back pain with calcifications and bone spurs are signs of bone periosteal infections of the bone lining surface cells. This protocol with tetracyclines like OxyTetracycline worked successfully. Fluoride, either sodium, calcium or stannous fluoride worked to suppress the growth of the calcifications.  In theory stannous fluoride, an ingredient in some tooth pastes should work best. But homeopathic calcium fluoride has been successful both for humans and horses.

Back pain was reduced or eliminated by rebooting the gut along with the following: Fluoride, either sodium, calcium or stannous fluoride worked to suppress the growth of the calcifications.  In theory stannous fluoride, an ingredient in some toothpastes should work best. But homeopathic calcium fluoride has been successful both for humans and horses.

Back pain with calcifications and bone spurs are signs of bone periosteal infections of the bone lining surface cells. This protocol with tetracyclines like OxyTetracycline worked successfully. Stannous fluoride would be an adjuvant to the therapy.

Case Histories:

Periosteal Arthritis, Ostio Myelitis Bone and Joint Infection:

Rapid Reversal by Ketosis, Minocycline and Ascorbic Acid and Peanuts

Ketosis plus vitamin C  (AA) is an adjuvant to the Tetracycline-antibiotic protocol. Combine Klenner's AA and Rheumatoid Arthritis” The Infection Connection, Appendix 2 tetracycline/minocycline protocol. Benign ketosis is induced by drastic reduction of carbohydrate intake to < 12 grams of carbohydrates per day. [See Dr. Atkins’ diet induction stage]

The liver shifts from fat storage mode to fat extraction mode and brown fats are catabolized to acetyl CoA to feed the Krebs (citric acid) cycle where ATP is made to feed energy to all the body cells. Body-cell sugar use shuts down. Hypo-glycemic condition stops in ketosis mode. 

Microbes and viruses are sugar dependent, so are drastically starved. ROS of the sickness oxidizes the AA to the DHA form. Microbes, microbe-infected body and cancer cells need sugar and ingest oxidized Dehydro Ascorbic Acid (DHA) instead.  Inside the microbes and the infected cells the DHA oxidizes the cells' mitochondria and induces apoptosis (cell death).

AA levels of about 28 grams per day were used in one case history on our website in addition to the Appendix 2 tetracycline protocol to reverse (cure) a severe painful bone-joint resident infection of unknown origin in a period of 4 days. Peanuts were used as an adjuvant to enhance the ROS. Stannous fluoride toothpaste was used to attack the calcifications.

Post treatment, eating honey-covered peanuts was enough to re-trigger the pain locus. The protocol was repeated successfully several times when relapse was induced by the sugar in orange juice. The periods of remission extended and severity of relapse decreased with each repetition of the ketosis and the combined protocols.

Comment-1: This was not a gentle protocol, because the microbes were fermenting, causing bone swelling and pain. The patient was a medical doctor who self treated, tuning modalities with food to induce flares quelled by near starvation ketosis.  Dietary citric acid was a positive nutrition factor for the fermenting microbe and had to be avoided, due to its role in the krebs cycle used by the various forms of the bacteria.

Comment-2: Add the nutrition in the next case history to further improve the gut microbiome.

Comment-3:  In cases of bone infections, sclerotic lesions, tumors, cysts, calcifications, etc; perfusion of the anti bacterial medicine is reduced considerably.  Adding carefully selected lysing enzymes to the protocol has greatly increased the ability of the other medicines to penetrate the protective wall.  Thus enzymes like papain, bromelain, and serrapeptase can increase the effectiveness of antibiotics and other medicines.

 

Remarkable Alzheimer’s Reversal by Ketosis diet and Coconut oil:

Alzheimer’s Disease Case History

Alzheimer's Disease: What If There Was a Cure? [Paperback]  by Mary Newport, MD

Amazon.com Book Description  Publication Date: October 7, 2011

“…Steve, first showed signs of Alzheimer's disease. [In 2000] After his deterioration accelerated in 2004, Dr. Newport began avidly researching ways to keep him functional for as long as possible.

“…she [found] research showing that medium-chain fatty acids, which act like an alternative fuel in the insulin-deficient Alzheimer's brain, can sometimes reverse or at least stabilize the disease. When she gave Steve about 2 tablespoons of coconut oil (a source of these fats) at breakfast before a memory test that he had previously failed, Steve miraculously passed the test. Since then, Steve continues to maintain improvement while taking daily doses of coconut oil and MCT (medium-chain triglyceride) oil with meals.

“… readily available fatty acids in foods that may reverse the ravages of this dreaded disease. Changes in loved ones may take many forms, including improved memory, return of personality, resumption of activities and social interaction, and relief from certain physical symptoms.

“Because ketone esters, a synthesized form of these powerful fatty acids, work faster and more comprehensively than fatty acids in foods, Dr. Newport has become an ardent advocate for ketone ester research, with FDA approval her final goal.

“..this book that summarizes Dr. Newport's research and Steve's reprieve, the importance of medium-chain fatty acids, and how Alzheimer's patients can make the transition to a healthy diet rich in these vital fats.”

Ketone ester vs Parkinson’s Trial:  NCT01364545, Enrolling at Oxford June, 2011.

Comment:  Lauric acid in coconut oil is antimicrobial systemically. It is antiviral in the gut. It is anti-arterial sclerosis too. Add to Coconut oil CoQ10 which increases blood flow to the brain. Take Red Palm oil and palm kernel oil, rich in alternate forms of Vitamins A and E. Vitamin A is antiviral. Palmitic acid in palm and coconut oil is also found in butter.

Palmitic acid is precursor for POPG1 a lung surfactant that reduces COPD microbes (both bacteria and virus) pathogenic action. POPG reduces the signaling by which the microbes can attract their target immune cells to invade.

Thus, immune-suppression minimizes walled colony formation and plaques, and facilitates antibiotic penetration. This potentates antibiotic action, increases kill rates, decreases relapse percentages from ~40% to 2% in case of TB bacteria treatment without any coconut oil adjuvant to the treatment. 

 

Alzheimers and Parkinson’s cofactors are likely to be at least some of the following microbes:

B.b, C.pn, Bartonella, Babesia,  All susceptible to antibiotic, ketone, tropic oils, Multifactor therapy

It is worth combining both this case history and the previous case history’s methods. Multiple adjuvants should work as shown in the mathematical formulas (above) to improve successful outcomes.

Ketonics and Coconut Oils vs Alzheimers  Case History
  1. Is Coconut Oil Effective for Alzheimer Disease? Gayle Nicholas Scott, PharmD
  2. Alzheimer’s Mild Dementia Instant Reversal Ketosis diet + tropical oils
  3. Dr. Mary Newport’s husband Steve treatment blog
  4. Mary’s Book: Alzheimer's Disease: What If There Was a Cure?

 

 

Gut Health Case Histories:

Fermenting Cabbage to Sauerkraut to Cure Gut Dysbiosis and Lactose Intolerance.

Contains a recipe.  For recovery from gut dysbiosis after antibiotic treatment of Giardia infection.

May be helpful for Crohn’s disease, gut dysbiosis, and lower back pain and ankylosing Spondylosis.

EMU Oil Case Histories:  Emu Oil:

Emu Oil, is high in oleic acid. Acts as a transport mechanism for medications into the body from the skin. It unclogs pores and is not irritating. It is anti-inflammatory and bacteria & fungus suppressing. It is used as a massage oil that transports to inside joints where it’s bacteriostatic and antifungal effects can kill off  joint and back microbial colonies.  It reduces inflammatory pain, swelling and stiffness in joints, and reduces pain of injuries and strains. It is stable, does not spoil and does not support microbe growth on the shelf.

Case Histories at HerbalHealer.com:

These case histories show emu oil is effective in reducing toe nail fungus, diabetic arthritis pain relief, sore & cracking skin, heals fungal-produced skin dryness, heals even severe diaper rash, normalizes chapped and scaling skin, eczema, improves psoriasis. Relieves minor back pain, bulging disks, tendonitis, and carpal-tunnel pain.

DMSO  DiMethyl Sulfoxide DMSO is a transport medium.

Warning: DMSO combined with oxygen therapies can be lethal. Metabolites of DMSO are nerve toxins. 

Two Emergency Room Disasters have been documented when a patient who drank DMSO was given oxygen, and the surrounding ER staff was overcome by the nerve gas produced. The one case in California is well documented. GOOGLE [emergency room nerve gas DMSO oxygen].

Topical DMSO is useful for sprained joints and to transport beneficial oils into joint areas. We used Methyl Salicylate (Oil of wintergreen) to treat tendon synovitis, carpal tunnel syndrome of the feet and ankles. Topical DMSO facilitates transport of both oil and water based chemicals through the skin into an inflamed part of the body and it helps the swollen area’s water removal.

Medically pure DMSO is available in health stores in the United States and on the Internet. Veterinarians to treat horses’ sprains, routinely, use DMSO topically.  DMSO only human FDA approved use is to treat interstitial cystitis (an epithelial bladder infection) using infusions via a catheter.

Dietary References: Books

Dr. Atkins’ Vita-Nutrient Solution: Nature’s Answer to Drugs   by Robert Atkins, M.D. Simon and Schuster, 1998, 1999, 407 pages.  Book-Finder Dr. Atkins has compiled a guide to nutrition for the person who is ill.  This authoritative and insightful compendium of vitamins, minerals, herbs, amino acids, and their restorative powers tells how they help the patient with serious medical conditions. Cancer, diabetes, MS, heart disease, arthritis, autism, vision problems, dental problems, skin conditions, CFS, fibromyalgia, autoimmune diseases, allergies, osteoporosis, scleroderma, urinary tract infections, pulmonary conditions, intestinal problems, men’s and women’s health, etc.  Dr. Poehlmann has recently been reading this book carefully and it is highly recommended. We plan to compile a better index to this wonderful book and publish it on our website.

 

Dr. Atkins’ Nutrition Breakthrough: How to Treat Your Medical Condition Without Drugs   by Robert Atkins, M.D. Bantam Books, 1982-86, 380 pages.  Book-Finder  Dr. Atkins was a cardiologist who embraced “natural,” complementary medicine, dietary modification, and nutrition to treat molecular imbalances that cause poor resistance to microbial colonization.  His low sugar/low carbohydrate diet, supplemented with appropriate vitamins is an effective way to control hyper/hypo-glycemia, bad cholesterol, yeast/fungal infections, and many specific chronic illnesses. His diet is based on the idea that all calories are not the same among fats, carbohydrates, and proteins. Each molecule has its own utilization effectiveness number that indicates how well its calories are used or not used as fuel or converted to body fat.

 

Dr. Atkins: New Diet Revolution by Robert Atkins, Harper, 2001, 560 pages. Book-Finder Our personal experience with his diet has confirmed several of his important claims. We found that a reduction in refined sugar and carbohydrates led to near elimination of yeast/fungal related hyperglycemic symptoms, including neuropathy, and also led to increased resistance to other infections.  This is the guide to how to induce the benign ketosis state of metabolism in your body.

 

The No-Grain Diet  by Alison Rose Levy and Joseph Mercola, Plume, 2004, 320 Pages  Book-Finder  The No-Grain Diet: Conquer Carbohydrate Addiction and Stay Slim for Life. For all of us refined carbs from grains provide many delicious but harmful treats that replace nutritious foods we should eat. Wheat can contribute to celiac allergies for some of us. Gluten allergies complicate some persons’ Autism inflammation. No-grains diet is organic vegetables and quality protein (avoid ocean fish), with limited fruits and absolutely no simple carbs. Refined grains are basically deadly and addictive.

Microbes vs diseases References:

A table of Wikipedia-listed associations of diseases with microbes is found on our website at www.RA-Infection-Connection.com/DiseasesAwMicrobes.htm  This table leaves out the well documented relationship between Alzheimer’s and Parkinson’s and the Lyme spirochete, it almost appears that there is a conspiracy to deny the obvious. See the next section for the many conditions associated with the B.b spirochete. It is well known that the spirochete of syphilis and B.b cause dementia in wild animals and humans. So why is it not on the chart for Parkinson’s and Alzheimer’s?
Many conditions are symptoms of Lyme: Borrelia = B.b and Chlamydia pneumonia = C.pn infections. 
Lyme causes symptoms misdiagnosed as: ADD/ADHD, Autism, Juvenile Arthritis, Rheumatoid Arthritis, Reactive Arthritis, Infectious Arthritis, Osteoarthritis, Fibromyalgia, Raynaud's Syndrome, Chronic Fatigue Syndrome, Interstitial Cystitis, Gastro-esophageal Reflux Disease, Fifth Disease, Multiple Sclerosis, Scleroderma, Lupus, early ALS, early Alzheimer’s, Crohn's disease, Ménières syndrome, Sjogren's syndrome, Irritable Bowel Syndrome, Colitis, Prostatitis, psychiatric disorders, bipolar, depression, Encephalitis, sleep disorders, thyroid disease to mention a few of 350 diseases that could possibly be Lyme or have B.b as an infectious, cell-invading cofactor.
This website contains the following table of Antibiotics Vs. Pulmonary Microbes:
Many systemic, arthritis and chronic inflammation causing microbes enter the body as acute pneumatic infections. So the following table gives a cross section list of the antibiotics that may be useful for treating chronic arthritis underlying persistent infections. 
Keep this in mind: so many tests of sera and fluids from the patients give false negatives when tested.  Once an infection, presume it is persistent, and is likely to be latent, hidden where tests do not detect and where immune system cannot wipe it out. COPD is a prime example. It may be better to treat all possible causes together or in rotating sequence: viral, bacterial and fungal, rather than restrict treatment to only the few microbes that show clear presence. A multi factored protocol with Minocycline, antiviral acyclovir, Tropic oils (palmitic) in diet, Serapeptase, and about 10+ to 20 grams of AA per day without ketosis significantly reduced chronic symptoms. “High” AA plus palmitic continues to prove an effective progression-stopping condition stabilizer. Concurrent control of hyperglycemia is also essential.
 
“Table 1: Oral Antibiotics Used in the Treatment of Acute Exacerbations of Chronic Bronchitis

Antibiotic

Spectrum of Activity and Resistance Pattern

Comments

Penicillins

 

 

Amoxicillin

No activity against atypical and beta-lactamase-producing bacteria
Penicillin resistance concerning with Streptococcus pneumoniae
Limited activity against Enterobacteriaceae

Resistance limits use

Amoxicillin-clavulanate

Activity against major pathogens
No activity against atypical bacteria
Penicillin resistance concerning with S. pneumoniae
Moderate activity against Enterobacteriaceae

More costly
Gastrointestinal side effects

Cephalosporins

 

 

General

Activity against major pathogens
No activity against atypical bacteria
Resistance concerning with S. pneumoniae
Moderate activity against Enterobacteriaceae

Alternative to beta-lactam agents and generally as effective

Second Generation

 

 

Cefaclor

Can be destroyed by Haemophilus influenzae and Moraxella catarrhalis enzymes

Associated with failure in patients with severe disease

Cefprozil

Moderate H. influenzae activity

 

Cefuroxime

 

 

Loracarbef

Moderate H. influenzae activity

 

Third Generation

 

 

Cefdinir

 

 

Cefibuten

No activity against Staphylococcus aureus
Marginal activity against S. pneumoniae

Poor gram-positive activity limits use

Cefixime

Poor activity against S. aureus

 

Cefpodoxime

 

 

Macrolides

 

Active against Mycobacterium avium. M. kansaii

General

Macrolide resistance concerning with S. pneumoniae
Active against atypical organisms
Not active against Enterobacteriaceae

 

Azithromycin

Greatest activity against H. influenzae

Short course of 3-5 days may be used.  Long term may cause hearing loss.

Clarithromycin

Greatest activity against S. pneumoniae

Alteration of taste may be an issue with bid dosing

Erythromycin

Poor activity against H. influenzae

Limited spectrum of activity

Tetracyclines

 

 

Doxycycline

Covers major pathogens and atypical organisms S. pneumoniae resistance is common

Maybe an alternative to quinolones and macrolides when atypical coverage is needed. See PMID: 21977068

Minocycline

Similar to doxycycline

 

Tetracycline

Limited activity against major pathogens
Active against atypical bacteria

Limited spectrum of activity

Fluoroquinolones

 

 

General

Active against all major pathogens, atypical pathogens, Enterobacteriaceae, and Pseudomonas aeruginosa

 

Ciprofloxacin

Least active against S. pneumoniae
Greatest activity against P. aeruginosa

Use if P. aeruginosa coverage is required

Gatifloxacin

Enhanced gram-positive activity

 

Levofloxacin

 

 

Moxifloxacin

Greatest activity against S. pneumoniae

 

Other

 

 

Trimethoprim-sulfamethoxazole

Covers major pathogens
No atypical coverage
S. pneumoniae resistance is common

Resistance limits use

 

Saturated Oils Nutrition Factors Technical References:

  1. National Accademy of Sciences: Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus–induced inflammation and infection http://www.pnas.org/content/107/1/320.full.pdf+html
  2. Journal of Biological Chemistry: Pulmonary Surfactant Phosphatidylglycerol Inhibits Mycoplasma pneumoniae-stimulated Eicosanoid Production from Human and Mouse Macrophages  http://www.jbc.org/content/286/10/7841.abstract  
  3. http://www.life-enthusiast.com/index/Articles/Enig/Coconuts_and_Oil:_Benefits  Quote:

“The properties that determine the anti-infective action of lipids are related to their structure, e.g., monoglycerides, free fatty acids. The monoglycerides are active; diglycerides and triglycerides are inactive. Of the saturated fatty acids, lauric acid(C-12) has greater antiviral activity than caprylic acid (C-8), capric acid (C-10) or myristic acid (C-14). 

“In general, it is reported that the fatty acids and monoglycerides produce their killing/inactivating effect by lysing the plasma membrane lipid bilayer.

“The antiviral action attributed to monolaurin is that of solubilising the lipids and phospholipids in the envelope of the virus, causing the disintegration of the virus envelope

 However, there is evidence from recent studies that one antimicrobial effect in bacteria is related to monolaurin's interference with signal transduction (Projan et al., 1994), and another antimicrobial effect in viruses is due to lauric acid's interference with virus assembly and viral maturation (Hornung et al., 1994).”

Palmitic(C:16) is also antibacterial and  reduces signal transduction.

  1. Weston A Price.org: Links to ABCs-of-Nutrition
  2. DC nutrition: THE HEALTHY RESURGENCE OF TROPICAL OILS: Coconut Oil.
  3. Mary Enig’s Papers: Google[enig coconut antiviral]
  4. http://www.life-enthusiast.com/index/Articles/Enig/The_Great_Con-ola
  5. http://www.life-enthusiast.com/index/Articles/Enig/Health_Risks_from_Trans_Fats
  6. http://www.life-enthusiast.com/index/Articles/Enig/Truth_About_Saturated_Fat
  7. http://www.life-enthusiast.com/index/Articles/Enig/The_Oiling_of_America
  8. http://www.life-enthusiast.com/index/Articles/Enig/Coconut_Oil:_A_New_Look
  9. http://www.life-enthusiast.com/index/Articles/Enig/Mary_Enig:_Biography
  10. http://www.seanet.com/~alexs/ascorbate/195x/klenner-fr-j_appl_nutr-1953-v6-p274.htm 

Dr Frederick Klenner: (1953) Early Clinical Usage of Vitamin C.  Quote:

“Our interest with vitamin C against the virus organism began ten years ago in a modest rural home. Here a patient who was receiving symptomatic treatment for virus pneumonia had suddenly developed cyanosis.

“He refused hospitalization for supportive oxygen therapy. X-Ray had been considered because of its dubious value and because the nearest department equipped to give such treatment was 69 miles distant.

“Two grams of vitamin C was given intramuscularly with the hope that the anaerobic condition existing in the tissues would be relieved by the catalytic action of vitamin C acting as a gas transport aid in cellular respiration.

“This was an old idea; the important factor being that it worked. Within 30 minutes after giving the drug (which was carried in my medical bag for the treatment of diarrhea in children) the characteristic breathing and slate-like color had cleared.

“Returning six hours later, at eight in the evening, the patient was found sitting over the edge of his bed enjoying a late dinner. Strangely enough his fever was three degrees less than it was at 2 P.M. that same afternoon.

“This sudden change in the condition of the patient led us to suspect that vitamin C was playing a role of far greater significance than that of a simple respiratory catalyst.

“A second injection of one gram of vitamin C was administered, by the same route, on this visit and then subsequently at six hour intervals for the next three days.

“This patient was clinically well after 36 hours of chemotherapy. From this casual observation we have been able to assemble sufficient clinical evidence that prove unequivocally that vitamin C is the antibiotic of choice in the handling of all types of virus diseases. Furthermore it is a major adjuvant in the treatment of at other infectious diseases.

 

“This experimental “strike” on vitamin C as an antibiotic opened a new avenue of approach to the problem of dealing with the virus bodies.

With a great deal of enthusiasm we decided to try its effectiveness with all of the childhood diseases. Measles was singled out more so than the others because of the knowledge that it was a small virus like the one causing poliomyelitis.

It was reasonable to assume that if measles could be controlled then Poliomyelitis, too, would have a drug that could prevent as well as cure the disease.

The use of vitamin C in measles proved to be medical curiosity. For the first time a virus infection could be handled as if it were a dog on a leash.

In the Spring of 1948 measles was running in epidemic proportions in this section of the country. Our first act, then, was to have our own little daughters play with children known to be in the “contagious phase.” When the syndrome of fever redness of the eyes and throat, catarrh, spasmodic bronchial cough and Koplik spots had developed and the children were obviously sick, vitamin C was started.

“In this experiment it was found that 1000mg every four hours, by mouth, would modify the attack. Smaller doses allowed the disease to progress. When 1000mg was given every two hours all evidence of the infection cleared in 48 hours.

If the drug was then discontinued for a similar period (48 hours) the above syndrome returned. We observed this of and on picture for thirty days at which time the drug (vitamin C) was given 1000 mg every 2 hours around the clock for four days.

This time the picture cleared and did not return. These little girls did not develop the measles rash during the above experiment and although exposed many times since still maintain this “immunity.”

Late cases were given the vitamin by needle. The results proved to be even more dramatic. Given by injection the same complete control of the measles syndrome was in evidence a 24 and 36 hour periods, depending entirely on the amount employed and the frequency of the administration.

Aborting of these cases before the development of the rash apparently gives no interference to the development of immunity. Recent progress on the rapidity of growth (a development) of the virus bodies by means of the electronic microscope makes intelligent the failure experienced by earlier workers when employing vitamin C on the virus organism (or bodies).

Unless the virus is completely destroyed, as demonstrated in the experiments with the virus using measles, the infection will again manifest itself after a short incubation period. Small, single daily doses do not even modify the course of the infection.”  

Note Recent PubMed article states:  “The blood half life of vitamin C is 30 minutes”  to deplete blood AA to ½ with no intake.

 

More Remarkable Klenner on Nutrition:  Multiple sclerosis (MS) and (MG)

Also see: http://www.townsendletter.com/Klenner/KlennerProtocol_forMS.pdf   Multiple sclerosis (MS) and (MG) myasthenia gravis recovery nutritional guidelines for vitamin dependencies where a much higher than normal dosage is therapeutic if given over a long enough time of several years.

Other References: Essential Nutrients, POPG Chemistry, Gut Health

  1.   On the Science of Essential Nutrients By John T.A. Ely

“Glycemic Control. Almost 2000 years ago in the time of Galen, it was observed that tumors grew poorly or not at all in underfed i.e., low [Blood Glucose] (BG) animals. In 1972, Ely deduced and related to Linus Pauling a theoretical reason why clinical trials of AA against colds and cancer might fail because of the high BG levels in the affluent nations. The theory is relevant to aging, birth defects, cancer, cardiovascular disease (CVD), infections, etc. It is called the "Glucose Ascorbate Antagonism" (GAA) and is important in the "small" dose range (AA~10g/d or less). It says that certain cell types such as leukocyte and fetal have intracellular AA levels that are "pumped up" largely by insulin ~50 times higher than serum AA levels in the surrounding blood. This occurs if BG is in the low range that was normal until the 1900's and is still seen today where the primitive (unrefined) diet prevails, i.e., 50-90 mg% two hours postprandial (Ely 1996; Chatterjee and Bannerjee, 1979, Table1). The high AA levels in such cells are needed to drive the HMP shunt to supply hydrogen peroxide for phagocytosis and ribose for mitosis. "Modest" BG elevations (~50%, common after western diet meals) competitively inhibit insulin-mediated active transport of AA into these cells, resulting in low intracellular AA levels, low HMP shunt, and cell dysfunction (i.e., leukocytes don't attack tumors or pathogens, fetal cells divide too slowly, etc.); this is the "Antagonism". It has been suggested that low BG may also cause the removal of negatively charged sialic acid (a 9-carbon sugar) from tumors that otherwise repel negatively charged T-cells. A principal cause of CVD is hyperglycemia which reduces AA to scorbutic levels in vascular intimal cells (see pp. 52-55 in Pauling 1987). The GAA theory gives rise naturally to "Aggressive Glycemic Control" (AGC) as a modality that, properly used, appears to have much value against many disorders as stated above.”

 

“Some Hypoglycemic Limits. Of course, one doesn't want BG too low because cortisol rises and can damage [cell mediated immunity] (cmi) by its lympholytic effects. Also, humans become unconscious (not necessarily harmful) below 40 mg%. Brain damage is reported to occur below 20 mg%. However, cmi is reported to work well down to ca 10 mg%. Cancer, infections and other diseases (CVD, etc) have much lower incidence with adequate AA and BG 50-90 mg%. In insulin-coma therapy, formerly used in the treatment of psychiatric patients, blood glucose was maintained circa 30 mg%. Incidental to this, remissions from cancer were reported to occur in patients whose incurable malignancies were unknown to the psychiatrist at the time of treatment (Koroljow, 1962). A more practical AGC might maintain BG at 50-60 mg% with insulin or Orinase (a non-halogenated oral hypoglycemic). Trivalent chromium deficiency in US soil and diet causes impaired glucose tolerance, high BG, and disease (Ely, 1996).”  See Glycemic Modulation of Tumor Tolerance  by John Ely in JoM.

 

15.    Am Soc for Microbiology: Mechanisms of Intracellular Killing of Rickettsia conorii in Infected Human Endothelial Cells, Hepatocytes, and Macrophages Hui-Min Feng and David H. Walker. Intracellular L- Tryptophan starvation kills rickettsia. Ascorbate: Deoxy AA, also kills intracellular forms. (Typhus)

 

  1. The Influence Of Vitamins On Infection By Melvin R Wierbach, The Townsend Letter,  Nov 2005

 

  1. http://www.ceci.ca/assets/uploads/PDF-FR/Karite/LipidsPharmaceuticalCosmeticPreparations.pdf

 

POPG Chemistry: Related to COPD and Palmitic Acid as Lung surfactant that suppresses microbe-immune signaling

  1. New Insights into Lung Surfactant Monolayers Using Vibrational Sum Frequency Generation Spectroscopy  G. Ma and H. C. Allen.
  2. http://www.cpnhelp.org/home  Chlamydia pneumonia chronic infection support group.

 

Gut Health:  See  Website Case Histories

  1. Fermented Cabbage Discussion Forum.

 

Ascorbic Acid, Hyper Glycemia, CoQ10 and Orthomolecular Nutrition

  1. UofWashington: Ely: Ascorbic Acid and Some Other Modern Analogs of the Germ Theory, 1999
  2. UofWashington: Ely: On Population Kinetics of an Aging Society:  Aging and Scurvy
  3. UofWashington: Ely: Glycemic Modulation of Tumor Tolerance Sugars feed Cancer
  4. UofWashington: Ely: On the Science of Essential Nutrients 2002  “Unprofitable Modalities”
  5. UofWashington: Ely: Hyperglycemia Epidemic   B6 and Nutrition
  6. UofWashington: Ely CoQ10 Summary of Ref Abstracts Physicians Update on CoQ10
  7. UofWashington: Ely & Krone: "Brief Update Ubiquinone = CoQ10"
  8. UofWashington: Ely & Krone: "Urgent Update Ubiquinone = CoQ10"   Turnover and daily consumption
  9. UofWashington: Ely Langsjoen "Intro to CoQ10" 
 

Papers on Vitamin C used in Ortho Medical Nutrition.  -- Klenner, Cathcart, Pauling, Stone 

29.   Irwin Stone: The Healing Factor: Vitamin C Against Disease, 1972  [THE ENTIRE BOOK IS FOUND HERE]

30.   OregonState.edu: Linus Pauling Institute  Vitamin C: Overview, history and  Pauling’s AA papers

  1. Theodore Jorgensen, Physicist, AA Letter,  November 2003:  Overview
  2. Historical VitaminC Ascorbate Articles 1930s to 1990s SeaNet Archive of many AA papers

Dr Robert Cathcart Papers:

  1. Dr Robert Cathcart: Medical Tribune Letter: Clinical Trial of Vitamin C (1975)
  2. Dr. Robert Cathcart: Medical Tribune Letter Vitamin C Function in AIDS (1983)
  3. Dr. Robert Cathcart: Preparing Vitamin C solution for IV/Injection use

Dr Frederick Klenner Papers:

  1. Dr. Klenner: Significance of High Daily Intake of Ascorbic Acid in Preventive Medicine
  2. Dr. Klenner on AA vs Polio cases of neural recovery
  3. Dr. Klenner: Observations On the Dose and Administration of Ascorbic Acid When Employed Beyond the Range of A Vitamin in Human Pathology
  4. Dr. Klenner's Clinical Guide to the Use of Vitamin C
  5. Dr. Klenner's Protocol for MS and Myasthenia Gravis
Dr Andrew Saul’s Doctor Yourself.com Reference List
  1. AA vs. Viral Diseases List and References Dr Saul’s Summary List

 

Other Vitamin C References:

  1. Fonorow: CO-Q10, Statins, Vitamin C  2003  Includes Bolenreport.com Headlines:
  2. L. Pauling:  Lysine/Ascorbate-Related Amelioration of Angina (Arterial Sclerosis) [JOM 1991] Remarkable Case History
  3. Linus Pauling: The [In-]Effectiveness of the National Cancer Institute   1977, After $billions, Still no AA studies. 2012 Update: the Stall goes on.
  4. Jungeblut’s Bio  At www.doctoryourself.com, Dr Andrew Saul’s website.
  5. Nobel prize 1937:  The Pioneers in Vitamin C Research
  6. DoctorYourSelf.com: Vitamin C: The Facts, The Fiction, and The Law  Thomas Levy MD, JD. Presentation, New Zealand Law.
  7. Supplemental Ascorbate in the Supportive Treatment of Cancer  Prolongation of Survival Times in Terminal Human Cancer
  8. Different Forms of Vitamin C, Linus Pauling Institute's Micronutrient Information Center
  9. Sweden Lund Univ: Dehydroascorbic acid clears Alzheimer plaques in mice
  10. Johns Hopkins: Vitamin C & E cut ICU deaths by 50%
  11. Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements
  12. Aloe vera gel increases bioavailability ~3x of vitamins C & E  

 

 

 

 

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