First News dated Feb 10, 2015.
Clarinex
(Desloratradine) in high in-vitro levels kills Borellia.
Desloratradine, Clarinex, disables the Mg transporter
mechanism and breaks down the spirochete's cell wall in Vitro tests.
"Amongst the probed compounds, desloratadine exhibited potent
borreliacidal activity in vitro at and above 78 µg/mL (250 µM). Borrelia treated with lethal doses
of desloratadine exhibited a significant loss of intracellular Mn specifically
and a severe structural damage to the bacterial cell wall."
Desloratradine
had the strongest effect. Clarinex not Claritin.
One
Blogger commented:
“Alas, looking at the details, one would have to
take several hundred times the normal dose of loratadine (or desloratadine which
loratadine is metabolized into) to approach the concentrations the researchers
were finding bactericidal in vitro (in test tube). The way I read it, they are
hoping 2 things: one, that such drugs will work better in vivo (in the body)
because of some technical details about how the borrelia bacteria are not
dependent on manganese in their culture preparation, and two, that they can
find some drug that works like desloratadine, but better.”
No
comments yet about combined Lyme therapy with Clarinex at normal doses with
anti bB antibiotics.
This
paper found 22 of 17 patients with Lyme resurgence had the new flare with a
different genotype of Bb. So it was a new infection, according to the
article, not a resurgence. Maybe AB
therapy works.
Bb Asian type, in Russia was wide-spread sampled, Baltic to Asia. All samples were found with genetic uniformity and matched the miyamotoi reference strain.
“Despite the great genetic distances between B. miyamotoi types, isolates within a type are characterized by an extremely low genetic variability. In particular, strains of B. miyamotoi of Asian type, isolated in Russia from the Baltic sea to the Far East, have been shown to be identical based on the analysis of several conventional genetic markers,…”
So,
perhaps one Lyme test can be developed for the Asian type Bb’s
miyamotoi strain
and other tests for the other Bb (European and Americans) genotype
strains. And one combined test can be made to test all the major strains of Bb
separately.
Google [desloratadine lyme
disease]
Using the common allergy antihistamine desloratadine may block
the manganese transporter in Borrelia burgdorferi, the cause of Lyme
disease, according to study results.Feb 13, 2015
www.healio.com/.../desloratadine-may-kill-lyme-disease-causing-bacteria
Feb 13, 2015 - Using the common allergy antihistamine desloratadine may block the manganese
transporter in Borrelia burgdorferi, the cause of Lyme disease, according
to study results.
lymediseaseresource.com/.../desloratadine-a-common-antihistamine-may...
Feb 14, 2015 - It is always good news when researchers find
something that discourages the stealthy and seemingly incurable Lyme disease. A
recent ...
forums.phoenixrising.me
› ... › Lyme Disease and Co-Infections Feb
10, 2015 - 17 posts - 9 authors http://lymedisease.org/news/lyme_disease_views/claritin-lyme-balf.html.
... The article is referring to desloratadine which is Clarinex not
Claritin. www.prnewswire.com/.../common-allergy-medication-may-be-effective-... Feb 10, 2015 - Lyme disease is a potentially
debilitating condition with 300,000 new ... (trade name: Claritin®)
and specifically its metabolite, desloratadine, ... www.empr.com
› News Feb 10, 2015 - Loratadine, an antihistamine found in
over-the-counter allergy medicines, may be able to help kill the bacteria
associated with Lyme disease ...