COPD
and Anti Infection Countermeasures: COPDcountermeasures.htm
Contents
2.
Cystic Fibrosis Lung Dysfunctions
3.
Specific Colonizing Microbes: Having a
respiratory component
4.
Fungus/Yeasts/Molds Immune suppressing and
respiratory inflaming
5.
Persistent Viruses Suppressing/exciting immune
system, cofactors in inflammation flares.
6.
Research related to the herpes viruses causing
diseases:
7.
Table 1 Human Herpesvirus Variants, Attributes, and
Relationships
8.
Respiratory Infection Bacteria List including many
pathogens
9.
Nutrition Factors: Tropical saturated fats
10.
Gut Inflammation Infections Many gut inflammations start as respiratory
infections
11.
COPD Treatments using diet changes, enzymes, and POPG aerosol.
12.
20 Specific Recommendations: Oils, Honey, Vitamin C, Serrapeptase, etc.
13.
Table 2 of Antibiotics Vs. Pulmonary Microbes:
14.
Dr Frederick Klenner: (1953) Early
Clinical Usage of Vitamin C. Quote:
Case history of rapid recovery
15.
References:
Tropic Oils, POPG, Klenner on Vitamin C
16.
References to our website content:
Summaries and notes from our Ongoing Research
COPD is a chronic inflammation
of the respiratory tract with some swelling which reduces the ease of breathing
and lung function. It has a
polymicrobial multi-factored cause with various components shifting to an acute
stage at times. The microbes involved
colonize epithelial airways surface lining cells and can invade immune cells
sent to kill/eat them. The microbe
colonies may have protective barriers that limit the transfer of antibiotics
into the colony. Proteolytic enzymes like serrapeptase can wipe out the
barriers, permit antibiotics to pass inside the colony, and reduce or wipe out
the colonies.
The established colonizing microbes form a
microbiome that brings many diverse genetic recipes, that colonize our cells
and, which changes our cells intrinsic chemical activities. Target cells that are colonized by multiple
microbes. This makes analysis of the resultant effects, (positive and negative)
hard to sort out. Genetic decoding of
the microbes RNA/DNA, including differences between microbe strains, are
providing new clues. Research is now describing how the invaders can influence
our cellular immune activities, molecule making and molecule using in our
chemical pathways.
COPD is caused by a persistent microbiome, which is
sensitive to antimicrobial, nutritional, and enzyme therapies. The following discussion identifies some of
the troublemakers and some of the methods of reducing the colony produced
pathogenicity.
Cystic Fibrosis (CF) is a respiratory disability
similar to COPD, which has a genetic cause. It is characterized by failure of
hydration of the epithelial cells of the respiratory tract and lungs. Infections play a part in the progressive
loss of breathing capacity. Bacteria Pseudomonas
aeruginosa colonizes many CF sufferers. It forms an antibiotic-resistant
biofilm in the lungs. Research shows for in a healthy mouse, glutathione levels
in the lungs can naturally rise 3x to prevent the bacteria from
colonizing. In the CF model there is no
increase of glutathione. Vitamin C in high blood levels regenerates oxidized
glutathione.
Treatments include doxycycline to control the
infection components. Liposomal AA
(L-AA), which is vitamin C (or alternatively sodium ascorbate) nano-coated with
lecithin and homogenized using ultrasound.
L-AA
has improved outcomes for CF with better pharmacokinetics
compared with AA. 98% of the
encapsulated AA transfers to the blood and blood, >5 times more than water
soluble AA. With L-AA, blood AA levels
higher than for AA IV have been produced. See L-AA
discussion. L-AA, 5 grams 2 x
per day, has produced progressive improvement of reduced lung capacity from ~
50% to over 85%.
L-AA is available on Amazon.com in multiple
forms. Other lipids --- Vitamin E,
CoQ10, and possibly coconut/palm/olive oils containing fatty palmitic and
lauric acids may in future be used to enhance antimicrobial actions. Quercetin has been suggested as a possible
Liposomal additive for cystic fibrosis.
Vitamin C Foundation has recent
blogs showing recovery of lung functions. This URL contains a large
list of research hot links to sites relating AA and cystic fibrosis
treatments. Since L-AA works when
combined with tetracycline antibiotics for Cystic Fibrosis and its infections,
it should also improve COPD lung functions using similar combined
multifactorial treatments. How AA Works
Microbes likely to cause or contribute to COPD
are: Fungus/Yeasts/Molds, Viruses, Bacteria
Fungus/Yeasts/Molds: Saccharomyces
cerevisiae, Candida albicans(?%) systemic infections;
Penicillium marneffei and Aspergillus fumigatus. Spread by
spores; pathogenicity depends on immune suppression, also suppresses immune
system.
Mostly RNA Respiratory Viruses,
(incidence%):
Picornaviruses,
tiny RNA( 36%), Enteroviruses including Coxsackie A & B
viruses targeting the gut epithelial cells; Paramyxoviridae,
RNA, PIV1-4, RSV, Respiratory
Syncytial Virus (22%), RNA;
Adenoviruses:
3,4,7,14 (10%), DNA; Influenza A
(25%) RNA; Rare respiratory SARS coronavirus large RNA; Rare
respiratory onset, UTI tropic, RNA Hantavirus.
Persistent
Viruses, suppressing/exciting immune system, cofactors in inflammation flares.
HHVs suppress MHC I & MHC II:
Human Herpes Viruses 1-9:
HSV-1&2, Herpes simplex 1&2;
HHV-3, Varicella, chicken pox;
HHV-4, Epstein Barr virus, EBV;
HHV-5, Cytomegalovirus, CMV blocks inflammatory cytokines;
HHV 6&7, Roseoloviruses, Roseola infantum, fatal encephalitis and persistent immune hypersensitivity
HHV-8, Kaposi’s sarcoma.
HHVs 6&7 can cause a fatal encephalitis. Could certain strains cause a nonfatal encephalitis and/or a drug/vaccine immune hypersensitivity and ASD inflammations? There is some evidence for this. HHV7 incidence is estimated to be 90%. Acute infection stage is in infancy when vaccinations take place. Many HHV6 and HHV7 infections have minimal symptomology. This hypothesis needs more investigation.
Research related to the herpes viruses causing diseases:
The co conditions include: Alzheimer's disease, atherosclerosis, cholangiocarcinoma, Crohn's disease, chronic fatigue syndrome, dysautonomia, fibromyalgia, Irritable bowel syndrome, multiple sclerosis, labile hypertension, lupus, pancreatic cancer, pancreatitis, pityriasis rosea, Type II Diabetes Links are to Wikipedia definitions.
Less well studied Herpes simian viruses infect laboratory monkeys used in vaccine research and vaccine production. These simian viruses may be contaminants of human and animal vaccines in both experiments and production. Since tests for the presence of these simian viruses do not exist, or are not used, the possibility of wide spread iatrogenic harm does exist. Vaccines can contain unintended live viruses or viral components as contaminants or as active agents. This has happened several times in the past and may happen again in the future. Infected HIB and Polio vaccines are past examples.
Table 1 Human Herpesvirus
Variants
|
HHV |
Name |
Abrev |
Incidence |
CoVirus that Makes worse |
Vaccine |
Assoc.Disease |
Target
& Latent |
|
1 & 2 |
Herpes Simplex:
Mouth-1, Genitals-2 |
HSV 1&2 |
HSV 50% |
HIV |
STD: Cold sores, lesions Alzheimers, Bells Palsy, Neuralgia |
Mucus epithelial cells & Latent in Nerve Cells |
|
|
3 |
Varicella, Herpes Zoster |
VZV, HZV |
90% |
HIV |
Yes Retro Virus meds work |
Chickenpox, shingles, Lupus (SLE) |
Mucus epithelial & Nerve cells |
|
4 |
Epstein Barr virus |
EBV |
75% |
Mutagenic |
Retro Virus meds work |
Chronic Fatigue Syndrome, Lupus, Lymphomas |
Epithelial & B immune cells |
|
5 |
Cytomegalovirus |
CMV |
60% |
Turns on Cancer genes |
Retro Virus meds work |
STD: Mononucleosis, Hepatitis, Heart Disease,
sclerotic cofactor |
|
|
6 |
Roseolovirus aka Herpes Lymphotropic virus |
HHV6 |
90% |
HIV in CD4-Tcells |
Retro Virus meds work |
Sixth disease (roseola
infantum) Multiple sclerosis cofactor with MSRV/HERV-W |
CD4+T cells and others TBD, Lymph system
epithelial? |
|
7 |
Roseolovirus |
HHV7 |
90% |
HIV in CD4-Tcells |
Retro Virus meds work |
Sixth disease (roseola
infantum) Recurrant & fatal Encephalitis, Drug
induced hypersensitivity |
CD4+T cells and nerve cells others (stem cells)
TBD |
|
8 |
Kaposi’s sarcoma |
KSHV |
Latent |
HIV activates pathogenic
modes |
Retro Virus meds work |
Cancer related to HIV Lymphomas |
Lymphocytes & B immune cells, and more? |
|
8+ |
Variants of KSHV |
HHV9 & 8+ |
Unknown |
HIV activates pathogenic
modes |
Retro Virus meds work |
HHV-8 pirates gene sequences; it is chimerical |
Lymphocytes & B immune cells, and more? |
Respiratory
infection bacteria include:
Streptococcus pyrogenes, rheumatic fever, scarlet
fever and necrotizing faschiitis;
Staphylococcus Aureus (co infection with cold
viruses);
Streptococcus pneumonia (many strains, aka pneumococcus,
rheumatic fever);
Mycoplasma pneumonia moves systemically and it
causes rheumatoid arthritis;
Other Mycoplasmas: M. fermentans, M.
hominis (arthritis), etc;
Ureaplasma, respiratory invasion moves to urinary tract,
cystitis;
Chlamydia pneumonia invades RT Epithelial
cells and moves system wide, poly-pathologies & highly persistent;
Chlamydia psittaci, Psittacosis,
aerosols, reservoir is birds; etc.
Yersinia entercolitica, acute respiratory invasion
moves to gut causes IBS & Ankylosing spondylitis;
Mycobacterium Paratuberculosis (milk, Johne’s Disease)
moves to gut causes IBS and Crohn’s disease;
Mycobacterium tuberculosis, respiratory TB and System
wide infections;
Legionella pneumophila, Legionnaires Disease;
Coxiella burnetii (Milk
aerosols, tics), Q-Fever;
Clostridium
difficile flare in the gut is a complicating factor in the gut
dysbiosis introduced by the antibiotics used to treat COPD. It is best treated in a hospital
environment; gut dysbiosis in a HMO service model with infrequent doctor
attention does not lead to rapid and effective identification and treatment.
Lack of certain tropical saturated fat
precursor components restricts hormone, and/or enzyme action, and also can lead
to immune system up disregulation.
Dietary fats propaganda has classified several essential precursor
saturated fats as harmful when they are not.
Tropical oils like coconut and palm contain vitamin complexes with
additional nutritional values.
Mary Enig described some effects of the U.S. diet:
low intake of tropical oils causes susceptibilities to microbes, e.g. HIV, RSV
and Mycoplasma pneumonia, Chlamydia pneumonia, etc, which form colonies
and invade cells which form a reservoir of microbes that are contributing
factors in COPD flares.
She also has noted neglected
papers that report insufficient butter intake in the presence of high
amounts of canola oil (Omega3) has lead to heart lesions. Rats died on canola
diet with no palmitic acid intake in two tests, one in Japan and one in Canada.
Saturated fat molecules are precursor molecules for essential molecules made in
the body. Tropical oils have been given
a bum rap. Oils intake needs balance, which is missing. (Refs: 7-12)
Restriction or elimination of essential
tropical fat precursors in our diet is contributing to gut and respiratory
dysbiosis. Lauric acid in coconut oil
converts to monolaurin (ML) in the gut. ML dissolves gut microbe’s lipid
coatings and interferes with their ability to bind to target cells. (Ref:
3) A surfactant, sodium lauryl sulfate,
a common detergent, might play a similar role, but simple monolaurin formed in
the gut is the safer alternative.
Sodium lauryl sulfate may be toxic if ingested.
The saturated fats from goats are richer that
other sources in Capric, Caproic , and Caprylic. Caprylic is especially antagonistic to yeast infections.
Palmitic acid, another saturated fat found in
butter is also essential as will be discussed in detail in following
paragraphs.
Gut Inflammation Infections:
HIV/AIDS, Measles/ASD, Yersinia entercolitica/Ankylosing Spondylitis Unk/lower
back pain.
HIV recovery or reversal has been multiply
reported based on coconut oil and/or vinegar, taken incessantly, as a drug,
multiple times a day. MMR live-vaccine sometimes causes chronic measles
gut-infection. Autism (ASD) neural inflammation
might be reduced if this infection is eliminated. High amounts of Vitamin A or
cod liver oil is antiviral.
Cleaning out the gut, sterilizing with
vinegar and water, Rebooting the gut flora and repopulating gut with
probiotics, buttermilk, and yogurt should help by revising the gut ecology.
Maintain new ecology with daily coconut and palm oils and refresh probiotics
with yogurt
cultures and live
yogurt cultured sauerkraut. For IBS, a cabbage fermented culture was found
to help. See: www.rejuvenative.com/catalog_one.htm
or find similar products in health stores. Buy one use for starter and make
your own fermentation with raw cabbage, lightly blended and yogurt with known
cultures. (Ref 17)
COPD treatment using diet changes, enzymes, and POPG
aerosol.
A palm oil derivative,
Palmitoyl-oleoyl-phosphatidyl-glycerol (POPG), a phospholipid surfactant,
normally found in the lungs, plays a complex beneficial role in binding to respiratory
synclinal virus (RSV), to Mycoplasma pneumoniae, and likely to other
COPD bacterial components. POPG interferes with the respiratory microbes’
ability to invade epithelial cells, to replicate, and to form
plaques/biofilms. It also interferes
with RSV’s ability to attach to molecules that stimulate immune reactivity.
(Refs: 1,2) POPG also reduces the
surface tension and viscosity of lung fluid and makes it easier to breathe.
A dietary intake low in
palm-derived oils, precursors to POPG, is likely to predispose to COPD, by
insufficiently blocking microbial ligand functions. Butter contains lots of
palmitic acid and small daily amounts are essential.
1.
Antibiotics
are useful for COPD flares.
Tetracyclines, and other antibiotics are useful. See
the table below. Antivirals and
anti Retroviral medicines effective against picoRNAviruses may also be
helpful. See 4, below. Antibiotics kill microbes causing the release of
endotoxins. This results in a flood of
oxides, which oxidize the antioxidant vitamins that are present. (Vitamin A, C,
E, and CoQ10) Specifically, vitamin C (A-AA) converts to DHA. More A-AA must be provided frequently to
keep the A-AA/DHA ratio in the healthy range much greater than 1.
2.
Add
butter, palm, palm kernel, and coconut oils to the diet in amounts of several
tablespoons, total per day. Use these oils in place of oils from peanut,
rapeseed = canola, corn, soybeans, cottonseed, etc. Vinegar taken daily has a
similar microbe coat-dissolving effect in the gut. These ingredients can be added appropriately to recipes or taken
separately as a supplement. Extra virgin olive oil is antimicrobial, as is
olive leaf extract.
3.
Vinegar,
raw honey and honeycomb are both antibacterial and anti-inflammatory. Dr D. C.
Jarvis in his book Folk Medicine (1958) Chapter 9 details case
histories demonstrating the benefits of chewing honeycomb to cure respiratory
inflammation. The combination of a few
tablespoons of apple cider vinegar and raw honey in 8 oz water taken 3 times
per day, before meals, reduces
high blood pressure and may reduce the pain of sore throat. Eating a small amount of raw honey may
reduce the respiratory irritation and inflammation of COPD and chewing honeycomb
or beeswax obtained from natural honey producers is noted by Dr Jarvis to be
immediately effective. Google
[honeycomb honey] or ask at your health food store. Beeswax and honey contain powerful antibiotic molecules with a
wide spectrum of antimicrobial effectiveness.
Honey is a good source for potassium and magnesium which may be in
too-low systemic levels. Vinegar facilitates calcium mobility in the body.
4.
Iota-Carrageenan
nasal spray Iota-Carrageenan is
antiviral against picoRNAviruses which include the rhinoviruses
that cause the common cold. Recently,
(2010) a study has proven that a seaweed derived food additive
molecule in nasal spray form can reduce inflammation-promoting molecules
associated with respiratory distress. “Pro-inflammatory mediators FGF-2,
Fractalkine, GRO, G-CSF, IL-8, IL-1α, IP-10, IL-10, and IFN-α2 were
reduced in the Iota-Carrageenan [treated] group.” Various forms of carrageenan have been used in food preparation
for hundreds of years in cultures worldwide, from Scotland to China and the
Philippine Islands where most of the world supply is made today. Carrageenan
also comes from California kelp. Nasal
spray can be prepared from dissolving the powder in sterile water, and before
it is jelled, it can be dispensed from a spray bottle, like with an
inhaler. This inexpensive spray costs
hundreds of dollars less than the cortisone-based sprays that suppress the
immune system without the beneficial antiviral actions that iota-carrageenan
provides. Research is ongoing towards
product development.
5.
The
enzyme Serapeptase is known to lyse fibrin, to liquefy mucus, and to destroy
respiratory bacterial biofilms. It
should be taken as needed to reduce congestion and facilitate breathing. It
liquefies phlegm. See our findings on Plaque
and Biofilm antibiotic resistance: Serrapeptase description. Mucinex which contains Guaifenesin operates
in a similar manner to lyse mucus and ease breathing.
6.
Ascorbic
acid 2-3 grams every 2 hours 12x /day for 4 days has controlled/eradicated wild
measles infections. (Klenner-13) The
same high dosage and intake rates may suppress viral respiratory infections.
Ascorbic acid improves blood oxygen transport. AA along with CoQ10 (>30
milligrams per day) work together to support cellular metabolism, boosting
available energy to the heart, brain and muscles. The AA molecule disables hyaluronidase, an enzyme produced by
pathogenic bacteria that use it as a spreading factor to dissolve tissues
containing hyaluronic acid and to increase bacterial mobility.
7.
Use
Liposomal
AA to produce higher AA blood
levels, similar to a high dosage IV sodium ascorbate treatment. Take
oral Liposomal AA (L-AA), about 5-7 grams every two hours. L-AA will have a transfer efficiency from
gut to blood of nearly 98 percent compared to the ~20% for oral AA. 4-5 days of this high dose L-AA should
elevate the active AA in the blood to the antimicrobial broad spectrum
antiviral killing level. These same
levels are those most effective to kill cancer cells and infected immune
cells. If a Herx reaction, back off or
lower dosage levels for a few days and resume, periodically until the toxin
load from the microbe die offs decreases to insignificance. If histamine is generated, antihistamines
may be helpful. ARB blockers also help stop the cytokine cascade of microbial
die off.
8.
See:
Vitamin C
(AA) Pharmacokinetics and Pharmacodynamics. AA is a universal toxin neutralizer molecule that must be ingested
like food because it is used up in the process. Tens of grams per day in dosages every 1-3 hours are needed in
severe toxin reactions and for acute infections. Sodium ascorbate is
administered by vein infusion (IV) for faster, more complete assimilation.
9.
Gut
dysbiosis implies a greater need for vitamins: E.g., Vitamin C, B6, B12, E, and
A, See Klenner
on Myasthenia Gravis for additional nutrition notes for difficult
vitamin dependencies where very high levels of nutrients are required by some
patients. Beware mineral deficiencies like magnesium.
10.
Vitamin
A from cod liver oil has reversed ASD
(see G Alpha protein) for a tunnel-blindness genetically predisposed
subpopulation. Megson Vitamin A is antiviral.
11.
Coconut
and palm oils if gently refined contain CoQ10, Vitamin E complex, and Vitamin A
complex molecules including multiple variants of Vitamin E’s tocopherols and
tocotrienols. This mix is a naturally nutritious feedstock for our chemical pathways
to make essential cholesterol molecules including both metabolic and steroid
hormones.
12.
Beware
statins
that block the mevalonate pathway that produces essential cholesterol, HEME and
CoQ10, leading to neural and muscular degeneration (Rhabdomyolysis),
pain and peripheral neuropathy. Statins reduce vital energy and oxygen
transport, leading to systemic degeneration of brain and muscle functions.
13.
Tetracycline
antibiotics: Minocycline, Doxycycline, and OxyTetracycline work against
Mycoplasma pneumonia and other “atypical pneumonia” bacteria in COPD. See our book Chapter 2 and see the Road
Back Foundation. Oral
antibiotics kill helpful gut bacteria. Reboot the gut microflora using plain
yogurt and buttermilk. See note 20 below.
14.
For
nutrition websites see references at our website.
15.
For
combined AA and other multi factors in a low sugar Ketonic protocol see our
website.
16.
See:
www.cpnhelp.org/home for help
with combined antibiotic protocols (CAP) for persistent Chlamydia pneumonia.
17.
A
steam inhalant is an effective technique for treating respiratory bronchitis,
catarrh and sinusitis. Mix 30 ml of compound tincture of Benzoin with 2.5 ml
eucalyptus oil or T-tree oil, Optionally add: 5 drops peppermint oil, 5 drops
lavender oil and 5 drops pine oil (or turpentine). Shake well in a small
bottle. Put a teaspoonful in a bowl and pour on 1 pt (500 ml) hot boiled water.
Cover the mouth and nose and the bowl with a towel or cloth and gently inhale
for a few seconds at a time. Keep the eyes closed and outside the tent. The
respiratory blockages will slowly clear and loosen. Repeat as necessary to free
up the breathing passages.
18.
Hypothetical
future treatment modality: POPG is available as a powder in small amounts (100
milligrams) but is expensive. It would
be needed in micrograms in an inhaler (~50ug/ml) It could be liquefied and
packaged in a spray bottle by a compounding pharmacy. This application has not
been studied or approved by the FDA.
19.
Hypothetical
treatment modality: Make your own Lecithin based Liposomal AA and add coconut, palm, vitamin A, Vitamin E, and
Vitamin C to the blend mix.
20.
Blend
raw sunflower seeds and add to no sugar plain yogurt, plus ice, plus frozen
berries, sugar free vanilla extract, and Xylitol for sweetening. Xylitol is a
sweetener that is strongly anti-yeast and it poisons sugar-loving microbes
forcing them to gene shift and mutate away from using the sugars in HFCS (corn
sugar). It has an anti plaque effect in the mouth and there are papers showing
Xylitol also forces a microbiome shift in the plaques and biofilms that coat
systemic epithelial surfaces in urinary tract, bladder, ear, and the
respiratory tract. See reboot the gut.
21.
Xylitol
nasal spray (XNS), when used repeatedly, is effective for quickly clearing
sinus infections and makes microbiome less plaque forming. Xylitol induces
bacteria gene expression changes that may last for weeks to months. Plaque molecules are also called endotoxins,
which play a role in causing inflammation and predisposing to ear infections.
Xylitol reprograms bacteria to stop making plaques and endotoxins. See Amazon
Reviews for Case Histories: XNS
Amazon Reviews See http://www.nasal-xylitol.com/ for
how it works. How to make nasal spray: Recipe.
More facts see our
Xylitol summary.
|
Antibiotic |
Spectrum of Activity and
Resistance Pattern |
Comments |
|
Penicillins |
|
|
|
Amoxicillin |
No activity against atypical and beta-lactamase-producing
bacteria |
Resistance limits use |
|
Amoxicillin-clavulanate |
Activity against major pathogens |
More costly |
|
Cephalosporins |
|
|
|
General |
Activity against major pathogens |
Alternative to beta-lactam agents and generally as
effective |
|
Second Generation |
|
|
|
Cefaclor |
Can be destroyed by Haemophilus influenzae and Moraxella
catarrhalis enzymes |
Associated with failure in patients with severe disease |
|
Cefprozil |
Moderate H. influenzae activity |
|
|
Cefuroxime |
|
|
|
Loracarbef |
Moderate H. influenzae activity |
|
|
Third Generation |
|
|
|
Cefdinir |
|
|
|
Cefibuten |
No activity against Staphylococcus aureus |
Poor gram-positive activity limits use |
|
Cefixime |
Poor activity against S. aureus |
|
|
Cefpodoxime |
|
|
|
Macrolides |
|
Active
against Mycobacterium avium. M. kansaii |
|
General |
Macrolide resistance concerning with S.pneumoniae |
|
|
Azithromycin |
Greatest activity against H. influenzae |
Short course of 3-5 days may be used. Long term may cause hearing loss. |
|
Clarithromycin |
Greatest activity against S. pneumoniae |
Alteration of taste may be an issue with bid dosing |
|
Erythromycin |
Poor activity against H. influenzae |
Limited spectrum of activity |
|
Tetracyclines |
|
|
|
Doxycycline |
Covers major pathogens and atypical organisms: Mycoplasma;
S. pneumoniae resistance is common |
Maybe an alternative to quinolones and macrolides when
atypical coverage is needed. See PMID: 21977068 |
|
Minocycline |
Similar to doxycycline |
|
|
Tetracycline |
Limited activity against major pathogens |
Limited spectrum of activity |
|
Fluoroquinolones |
|
|
|
General |
Active against all major pathogens, atypical pathogens, Enterobacteriaceae,
and Pseudomonas aeruginosa |
|
|
Ciprofloxacin |
Least active against Strep. pneumoniae |
Use if P. aeruginosa coverage is required |
|
Gatifloxacin |
Enhanced gram-positive activity |
|
|
Levofloxacin |
|
|
|
Moxifloxacin |
Greatest activity against Streptococcus pneumoniae
|
|
|
Other |
|
|
|
Trimethoprim-sulfamethoxazole |
Covers major pathogens |
Resistance limits use |
Dr
Frederick Klenner: (1953) Early Clinical Usage of Vitamin C. Quote:
“Our interest with vitamin C
against the virus organism began ten years ago in a modest rural home. Here a
patient who was receiving symptomatic treatment for virus pneumonia had suddenly
developed cyanosis. He refused hospitalization for supportive oxygen therapy.
X-Ray had been considered because of its dubious value and because the nearest
department equipped to give such treatment was 69 miles distant. Two grams of
vitamin C was given intramuscularly with the hope that the anaerobic condition
existing in the tissues would be relieved by the catalytic action of vitamin C
acting as a gas transport aid in cellular respiration.
“This was an old idea; the
important factor being that it worked. Within 30 minutes after giving the drug
(which was carried in my medical bag for the treatment of diarrhea in children)
the characteristic breathing and slate-like color had cleared.
“Returning six hours later, at
eight in the evening, the patient was found sitting over the edge of his bed
enjoying a late dinner. Strangely enough his fever was three degrees less than
it was at 2 P.M. that same afternoon. This sudden change in the condition of
the patient led us to suspect that vitamin C was playing a role of far greater
significance than that of a simple respiratory catalyst.
“A second injection of one
gram of vitamin C was administered, by the same route, on this visit and then
subsequently at six hour intervals for the next three days. This patient was
clinically well after 36 hours of chemotherapy. From this casual observation we
have been able to assemble sufficient clinical evidence that prove
unequivocally that vitamin C is the antibiotic of choice in the handling of all
types of virus diseases. Furthermore it is a major adjuvant in the treatment of
at other infectious diseases.
“This experimental “strike”
on vitamin C as an antibiotic opened a new avenue of approach to the problem of
dealing with the virus bodies. With a great deal of enthusiasm we decided to
try its effectiveness with all of the childhood diseases.
“Measles was singled out
more so than the others because of the knowledge that it was a small virus like
the one causing poliomyelitis. It was reasonable to assume that if measles
could be controlled then Poliomyelitis, too, would have a drug that could
prevent as well as cure the disease.
“The use of vitamin C in
measles proved to be medical curiosity. For the first time a virus infection
could be handled as if it were a dog on a leash. In the Spring of 1948 measles
was running in epidemic proportions in this section of the country. Our first
act, then, was to have our own little daughters play with children known to be
in the “contagious phase.” When the syndrome of fever redness of the eyes and
throat, catarrh, spasmodic bronchial cough and Koplik spots had developed and
the children were obviously sick, vitamin C was started.
“In this experiment it was
found that 1000mg every four hours, by mouth, would modify the attack. Smaller
doses allowed the disease to progress. When 1000mg was given every two hours
all evidence of the infection cleared in 48 hours. If the drug was then
discontinued for a similar period (48 hours) the above syndrome returned.
“We observed this of and on
picture for thirty days at which time the drug (vitamin C) was given 1000 mg
every 2 hours around the clock for four days. This time the picture cleared and
did not return.
“These little girls did not
develop the measles rash during the above experiment and although exposed many
times since still maintain this “immunity.” Late cases were given the vitamin
by needle. The results proved to be even more dramatic. Given by injection the
same complete control of the measles syndrome was in evidence a 24 and 36 hour
periods, depending entirely on the amount employed and the frequency of the
administration.
“Aborting of these cases
before the development of the rash apparently gives no interference to the
development of immunity. Recent progress on the rapidity of growth (a
development) of the virus bodies by means of the electronic microscope makes
intelligent the failure experienced by earlier workers when employing vitamin C
on the virus organism (or bodies). Unless the virus is completely destroyed, as
demonstrated in the experiments with the virus using measles, the infection
will again manifest itself after a short incubation period. Small, single daily
doses do not even modify the course of the infection.”
Note Recent PubMed article
states: “The blood half life of vitamin
C is 30 minutes” with no intake.
See Vitamin C Foundation: It’s
the Dosage Stupid.
If the AA dosage is low or
infrequent, AA does not work effectively as an antibiotic and an
antiviral. AA at nutritional levels is
never enough AA blood concentration to work as an antibiotic/antiviral. Thus
the poor results in study after study. Once the proper AA blood concentrations
are maintained by frequent AA intake, then the remarkable healing actions of AA
become evident. See: How
much vitamin C.
We have observed a COPD
exacerbation due to AA depletion accompanied by systemic (Cypro-induced
endotoxin) toxemia and with serious congestive heart/lung dysfunctions. Once enough AA was administered every 2
hours, with CoQ10 supplementation, and Angiotensin Release Blockers (ARBs)
blocked the cytokine inflammation cascade, continued IV antibiotics for several
days, oxygen therapy, recovery of heart and lung function was remarkably swift,
and to a improved level of respiratory functioning. The needed AA level to
sustain the recovery was greater than 12 grams per day for 135-pound
patient. Dosage: 1-3 grams of AA every
1-3 waking hour and AA during the night if awakened to relieve bladder. Liposomal
AA would provide better pharmacokinetics at a lower AA dosage.
“The properties that determine the anti-infective action of lipids are
related to their structure, e.g., monoglycerides, free fatty acids. The
monoglycerides are active; diglycerides and triglycerides are inactive. Of the
saturated fatty acids, lauric acid(C-12) has greater antiviral activity than
caprylic acid (C-8), capric acid (C-10) or myristic acid (C-14). In general, it is reported that the fatty
acids and monoglycerides produce their killing/inactivating effect by lysing
the plasma membrane lipid bilayer. The antiviral action attributed to
monolaurin is that of solubilising the lipids and phospholipids in the envelope
of the virus, causing the disintegration of the virus envelope. However, there
is evidence from recent studies that one antimicrobial effect in bacteria is
related to monolaurin's interference with signal transduction (Projan et al.,
1994), and another antimicrobial effect in viruses is due to lauric acid's
interference with virus assembly and viral maturation (Hornung et al., 1994).”
Abstract The progression and exacerbations of chronic obstructive pulmonary disease (COPD) are intimately associated with tobacco smoke/biomass fuel-induced oxidative and aldehyde/carbonyl stress. Alterations in redox signaling pro-inflammatory kinases and transcription factors, steroid resistance, unfolded protein response, mucus hypersecretion, extracellular matrix remodeling, autophagy/ apoptosis, epigenetic changes, cellular senescence/aging, endothelial dysfunction, autoimmunity, and skeletal muscle dysfunction are some of the pathological hallmarks of COPD. In light of the above it would be prudent to target systemic and local oxidative stress with agents that can modulate the antioxidants/redox system or by boosting the endogenous levels of antioxidants for the treatment and management of COPD. Identification of various antioxidant agents, such as thiol molecules (glutathione and mucolytic drugs, such as Nacetyl-L-cysteine and N-acystelyn, erdosteine, fudosteine, ergothioneine, and carbocysteine lysine salt), dietary natural product-derived polyphenols and other compounds (curcumin, resveratrol, green tea catechins, quercetin sulforaphane, lycopene, acai, alpha-lipoic acid, tocotrienols, and apocynin) have made it possible to modulate various biochemical aspects of COPD. Various researches and clinical trials have revealed that these antioxidants can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling, and ultimately inflammatory gene expression. In addition, modulation of cigarette smoke induced oxidative stress and related cellular changes have also been reported to be effected by synthetic molecules. This includes specific spin traps like α- phenyl-N-tert-butyl nitrone, a catalytic antioxidant (ECSOD mimetic), porphyrins (AEOL 10150 and AEOL 10113), and a superoxide dismutase mimetic M40419, lipid peroxidation and protein carbonylation blockers/inhibitors, such as edaravone and lazaroids/tirilazad, myeloperoxidase inhibitors, as well as specialized pro-resolving mediators/inflammatory resolving lipid mediators, omega-3 fatty acids, vitamin D, and hydrogen sulfide. According to various studies it appears that the administration of multiple antioxidants could be a more effective mode used in the treatment of COPD. In this review, various pharmacological and dietary approaches to enhance lung antioxidant levels and beneficial effects of antioxidant therapeutics in treatment or intervening the progression of COPD have been discussed.
References
to our website content:
More Klenner on Nutrition:
Also see: http://www.townsendletter.com/Klenner/KlennerProtocol_forMS.pdf
Multiple sclerosis and myasthenia
gravis recovery nutritional guidelines for vitamin dependencies
where a much higher than normal dosage is therapeutic if given over a long
enough time of several years.
Other References: